cas 339017-83-3, 6-CHLORO-N-ETHYL-2-(METHYLSULFANYL)-4-PYRIMIDINAMINE | Articles data ｜lookchem

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339017-83-3

Articles about 339017-83-3Total 3 be found

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Discovery of High-Affinity Inhibitors of the BPTF Bromodomain
The dysfunctional bromodomain PHD finger transcription factor (BPTF) exerts a pivotal influence in the occurrence and development of many human diseases, particularly cancers. Herein, through the structural decomposition of the reported BPTF inhibitor TP-
Lu, Tian,Lu, Haibo,Duan, Zhe,Wang, Jun,Han, Jie,Xiao, Senhao,Chen, HuanHuan,Jiang, Hao,Chen, Yu,Yang, Feng,Li, Qi,Chen, Dongying,Lin, Jin,Li, Bo,Jiang, Hualiang,Chen, Kaixian,Lu, Wenchao,Lin, Hua,Luo, Cheng
p. 12075 - 12088
(2021/09/02)

NEW PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS (PDE-10)
The present invention relates to novel pyrimidine derivatives of formula (I)[Formula should be entered here] as inhibitors of the enzyme phosphodiesterase 10 (PDE-10), pharmaceutical compositions comprising an effective amount of these compoundsand theuse of the compounds for manufacturing a medicamentfor thetreatment ofpathological conditions or diseases that can improve by inhibition of the enzyme Phosphodiesterase such as neurological, psychiatric, respiratory or metabolic diseases.
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Page/Page column 31; 32

(2014/08/07)

Identification of aminopyrimidine regioisomers via line broadening effects in1H and13C NMR spectroscopy
Substituted mono- and diamino-pyrimidines were synthesized as part of our medicinal chemistry programmes. Primary amines substituted at the 4-position exhibited room-temperature line broadening effects in both 1H and 13C NMR spectros
Garner, James,Hill, Tim,Odell, Luke,Keller, Paul,Morgan, Jody,McCluskey, Adam
p. 1079 - 1083
(2007/10/03)

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Chemical Properties

Boiling Point: 345.1 °C at 760 mmHg
Flash Point:162.5 °C
Density: 1.29 g/cm³
PSA: 63.11000
LogP: 2.35670

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