- Highly efficient hydrogenation reduction of aromatic nitro compounds using MOF derivative Co-N/C catalyst
-
The direct hydrogenation reduction of aromatic nitro compounds to aromatic amines with non-noble metals is an attractive area. Herein, the pyrolysis of Co(2-methylimidazole)2 metal-organic framework successfully produces a magnetic Co-N/C nanocomposite, which exhibits a porous structure with a high specific area and uniform Co nanoparticle distribution in nitrogen-doped graphite. In addition, the Co-N/C catalysts possess high cobalt content (23%) with highly active β-Co as the main existing form and high nitrogen content (3%). These interesting characteristics endow the Co-N/C nanocomposite with excellent catalytic activity for the hydrogenation reduction of nitro compounds under mild conditions. In addition, the obtained Co-N/C nanocomposites possess a broad substrate scope and good cycle stability for the reduction of halogen-substituted or carbonyl substituted phenyl nitrates. This journal is
- Dai, Yuyu,Li, Xiaoqing,Wang, Likai,Xu, Xiangsheng
-
p. 22908 - 22914
(2021/12/24)
-
- Convenient semihydrogenation of azoarenes to hydrazoarenes using H2
-
The high atom-economical and eco-benign nature of hydrogenation reactions make them much more superior to conventional reduction and transfer hydrogenation. Herein, a convenient and highly selective hydrogenation reaction of azoarenes using molecular hydrogen to access diverse hydrazoarenes is reported. The present catalytic method is general and operationally simple, and it operates under exceedingly mild conditions (room temperature and 1 atm of hydrogen pressure). The reusability of catalysts used in this method is also successfully demonstrated.
- Sahoo, Manoj K.,Sivakumar, Ganesan,Jadhav, Sanjay,Shaikh, Samrin,Balaraman, Ekambaram
-
supporting information
p. 5289 - 5293
(2021/06/30)
-
- COMPOUNDS USEFUL IN HIV THERAPY
-
The invention relates to compounds of Formula (I), (Ia), (Ib), (II) or (III), salts thereof, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.
- -
-
Page/Page column 150
(2020/06/19)
-
- Diphenyl ethane diisocyanate and preparation method thereof
-
The invention discloses diphenyl ethane diisocyanate and a preparation method thereof, and relates to the technical field of high molecular material monomer preparation. The diphenylethane diisocyanate has a structure shown in the specification, wherein R is H or alkyl, and a substituent R is positioned at a 2 (2') site or a 3 (3') site; substituent -NCO is located at a 4 (4') site or a 5 (5') site or a 6 (6') site; EDI serves as a polyurethane monomer to be applied to polyurethane materials and comprises polyurethane foam, a polyurethane adhesive, polyurethane synthetic leather, a polyurethane fabric coating layer, a polyurethane resin coating, a polyurethane elastomer and other synthetic materials.
- -
-
Paragraph 0042-0043
(2020/04/29)
-
- Synthesis method of iminodibenzyl
-
The invention relates to the field of drug intermediate synthesis, in particular to a synthesis method of iminodibenzyl, which mainly comprises two steps: a reduction reaction and a cyclization reaction. The yield can be improved to 88%-92% through fine control of the reduction reaction and the cyclization reaction, and the synthesis method has great industrial significance and is worthy of further popularization.
- -
-
Paragraph 0006; 0016-0017; 0019; 0020-0027
(2020/07/02)
-
- Method for preparing medicine and medicine intermediate by continuous solid-liquid-gas three-phase reaction
-
The invention provides a method for preparing meropenem or a 10,11-dihydro-5H-dibenzo[b, f] azepine by a continuous solid-liquid-gas three-phase reaction. A reactant in which acatalyst is dissolved ispumped into a microchannel reactor by using a diaphragm pump, and the hydrogen is bubbled into the reactor by using the pressure of a steel cylinder. The method uses the microchannel reactor to realize the continuous production of the meropenem or the 10,11-dihydro-5H-dibenzo[b, f] azepine. The technical effects of short reaction time, thorough reaction and high product yield are achieved.
- -
-
Paragraph 0043; 0044; 0045
(2018/07/30)
-
- Preparation method of 2,2'-diamino bibenzyl
-
The invention discloses a method for preparing 2,2'-diamino bibenzyl by virtue of a catalysis method and a preparation method of an adopted catalyst. The method comprises the step of carrying out normal-temperature reaction on the raw material, namely ortho-nitrochlorobenzyl, at a normal pressure in a water phase by virtue of a one-pot method, so as to obtain the target product. Compared with a traditional preparation method, the method has the advantages that the reaction time is greatly shortened, the production efficiency is high, the catalyst can be repeatedly used, and the product yield is moderate; no strong base is used in the whole production process, so that acid neutralization is omitted; and the reaction solvent is not an organic solvent, so that the treatment difficulty of three wastes is low, and the industrial application value is high.
- -
-
Paragraph 0014-0015; 0016-0017
(2017/12/29)
-
- Synthesis and spectroscopic characterization study of some cyclic-azodioxides
-
New compounds of cyclic-azodioxides have been prepared by oxidation of the corresponding diamines with sodium tungstate and hydrogen peroxide in a mixed ethanol/water solvent. Spectroscopic techniques, including IR, UV, 1H NMR, and 13C NMR, and CHN analysis were used to identify the products. In solution, the azodioxides were found to be in equilibrium with the corresponding dinitroso compounds. The IR values of the synthesised compounds are in agreement with the theoretical IR spectra. The Japan Institute of Heterocyclic Chemistry.
- Al-Magmoy, Mohammad A. Naser,Al-Shamkhani, Zeki A. Nasir,Essa, Ali Hashem
-
scheme or table
p. 2807 - 2815
(2011/04/16)
-
- Synthesis of new dibenzo[b,f]azepine derivatives
-
This work is focused on synthesis and chemical characterization of new polycyclic compounds having dibenzo[b,f] azepine and 10,11-dihydrodibenzo[b,f] azepine moieties. We report the synthesis of four new compounds, obtained by reacting 5H-dibenzo[b,f]azepine-5-carbonyl chloride and 10,11-dihydro-5H- dibenzo[b,f]azepine-5-carbonyl chloride with 1-phenylpiperazine, and pyrrolidine, respectively. The newly synthesized compounds were characterized using chromatographic and spectroscopic methods (HPLC-UV-VIS 1H-NMR, 13C-NMR, mass spectrometry by ESI technique).
- Balaure, Paul Catalin,Costea, Ion,Iordache, Florin,Draghici, Constantin,Enache, Cristian
-
scheme or table
p. 935 - 942
(2011/06/21)
-
- Hydrazinium monoformate: A new hydrogen donor. Selective reduction of nitrocompounds catalyzed by commercial zinc dust
-
The nitro group in aliphatic and aromatic nitro compounds also containing reducible substituents such as ethene, nitrile, acid, phenol, halogen, ester, etc., are selectively and rapidly reduced at room temperature to corresponding amines in good yields by employing hydrazinium monoformate, in the presence of commercial zinc dust. It was observed that, hydrazinium monoformate is more effective than hydrazine or formic acid and reduction of nitro group occurs without hydrogenolysis in the low cost zinc dust compared to expensive metals like palladium.
- Gowda, Shankare,Gowda, B. K. Kempe,Gowda, D. Channe
-
p. 281 - 289
(2007/10/03)
-
- Catalytic transfer hydrogenation of aromatic nitro compounds by employing ammonium formate and 5% platinum on carbon
-
Aromatic nitro compounds were reduced to respective amines in high yields by using 5% platinum on carbon with ammonium formate or formic acid as hydrogen donor. It was observed that the former was mote efficient donor than the later. Further we have found that reduction of nitro groups occurs without hydrogenolysis of halogens and the reducible substituents which remains unchanged under the reaction conditions.
- Gowda,Mahesh
-
p. 3639 - 3644
(2007/10/03)
-
- Formic acid with 10% palladium on carbon: A reagent for selective reduction of aromatic nitro compounds
-
The nitro group in aromatic nitro compounds also containing reducible substituents such as carbonyl, ethene, ethyne, nitrile, acid, phenol etc, is selectively and rapidly reduced at room temperature to corresponding amino derivatives in good yield employing formic acid in the presence of 10% palladium on carbon. The catalyst could be recovered and reused after washing with water and ethanol, and the results obtained indicate further, there is no apparent loss of catalytic activity.
- Channe Gowda,Gowda
-
p. 709 - 711
(2007/10/03)
-
- Synthesis of Indoles via Ring Closure of 2-Alkylnitroaniline Derivatives.
-
A variety of nitroindoles have been prepared from imidate, amidine, and sec-anilide derivatives of 2-alkyl-3- or 5-nitroanilines by a base-induced cyclization promoted by dialkyl oxalates.It is shown that essentially the same procedure also can be used to synthesize the corresponding nitroindole-3-glyoxylates in one simple operation.The synthetic potential is discussed and a mechanism is proposed.
- Bergman, Jan,Sand, Peter
-
p. 6085 - 6112
(2007/10/02)
-
