- Indole synthesis: palladium-catalyzed C-H bond amination via reduction of nitroalkenes with carbon monoxide
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Nitroalkenes have been called 'chemical chameleons' due to their versatility in numerous synthetic transformations. Herein, we describe the first transition metal-catalyzed transformation of conjugated nitroalkenes into indoles. Under mild reaction condit
- Hsieh, Tom H.H.,Dong, Vy M.
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experimental part
p. 3062 - 3068
(2009/09/05)
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- Reduction of 2,2-Diaryl-1-nitroethylenes : New Synthesis of 2,2-Diarylacetaldehydes and 1,1,4,4-Tetraarylbuta-1,3-dienes
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2,2-Diarylacetaldehydes (VII) have been obtained by selective and controlled reduction of 2,2-diaryl-1-nitroethylenes (IV) in acid medium, and also by acid hydrolysis of 2,2-diarylvinyl-N-acetamides (VI).Nitroalkenes (IV) have been prepared by the reaction of 2,2-diarylethylenes (I) with nitrous acid whereas N-acetamide derivatives (VI) have been obtained by reductive acetylation of the nitro compounds (IV).A number of 1,1,4,4-tetraarylbuta-1,3-dienes (XI) have been obtained by the condensation of 2,2-diarylacetaldehydes (VII) with appropriate 2,2-diarylethylenes (I).Structures of the products have been assigned on the basis of analytical data and chemical and spectral evidences.
- Tadros, Wadie,Awad, Sami B.,Sakla, Alfy B.,Abdul-Malik, Nadia F.,Armanious, Emili R.
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p. 199 - 202
(2007/10/02)
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