- Cytotoxic diterpenoids and sesquiterpenoids from Pteris multifida
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Three new ent-kaurane diterpenoids, named pterokaurane M1-M 3 (1-3) and three new C14 pterosin-sesquiterpenoids, named multifidoside A-C (4-6), along with 18 known compounds, were isolated from the whole plants of Pteris multifida. The structures of 1-6 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Compounds 4 and 5 showed cytotoxicity against the HepG2 tumor cell line with IC50 values of less than 10 μM.
- Ge, Xin,Ye, Guan,Li, Ping,Tang, Wen-Jie,Gao, Jin-Li,Zhao, Wei-Min
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- PTAQUILOSIDE, A POTENT CARCINOGEN ISOLATED FROM BRACKEN FERN PTERIDIUM AQUILINUM VAR. LATIUSCULUM: STRUCTURE ELUCIDATION BASED ON CHEMICAL AND SPECTRAL EVIDENCE, AND REACTIONS WITH AMINO ACIDS, NUCLEOSIDES, AND NUCLEOTIDES
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The structure of ptaquiloside (I), a potent carcinogenic compound isolated from bracken fern, Pteridium aquilinum var. latiusculum has been elucidated on the basis of chemical and spectral evidence.The dienone 3 generated from 1 under alkaline conditions was shown to be a strong alkylating agent.For the purpose of obtaining the preliminary information on chemical modification of biopolymers such as proteins and DNA with the dienone 3, reactions of 3 with amino acids, nucleosides, and nucleotides have been carried out and the alkylated products have been characterized.
- Ojika, Makoto,Wakamatsu, Kazumasa,Niwa, Haruki,Yamada, Kiyoyuki
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p. 5261 - 5274
(2007/10/02)
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