Compounds of the formula I in which R1, R2, R3, R4 and R5 are each as defined in claim 1 are inhibitors of cell proliferation/cell vitality and can be used to treat tumors.
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Page/Page column 11-12
(2010/07/10)
Synthesis of the indole alkaloids meridianins from the tunicate Aplidium meridianum
The marine natural products meridianins A and C-E have been synthesized for the first time starting from the appropriate N-tosyl-3-acetylindole. A facile two-step conversion of N-tosyl-3-acetylindoles to the corresponding meridianins by treatment with dimethylformamide dimethylacetal and further cyclization of the resulting enaminone with aminoguanidine is described. This method has also been applied for the preparation of the 3-[(2-amino)pyrimidin-4-yl]-7-azaindole.
Fresneda, Pilar M,Molina, Pedro,Bleda, Juan A
p. 2355 - 2363
(2007/10/03)
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