Transfer Hydration of Dinitriles to Dicarboxamides
We present a robust method for double transfer hydration of dinitriles to afford diamides. The transfer hydration of 1, n -dinitriles (n = 1-6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure.
Naka, Hiroshi,Naraoka, Asuka
supporting information
p. 1977 - 1980
(2019/10/22)
RhI-catalyzed hydration of organonitriles under ambient conditions
(Chemical Presented) New scoop on scope and selectivity: The hydration of organonitriles catalyzed by a RhI(OMe) species under nearly pH-neutral and ambient conditions (25°C, 1 atm) is chemoselective and high-yielding (93 to 99%), has a broad substrate scope, and may thus be complementary to enzymatic hydration methods for the introduction of a terminal amido group (CONH2) onto a carbon chain.
Goto, Akihiro,Endo, Kohei,Saito, Susumu
p. 3607 - 3609
(2008/12/23)
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