Compounds for treating and preventing diabetic complications
This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, wherein R is as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.
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(2008/06/13)
Substituted pyrimidine derivatives, a process for the preparation thereof and the use thereof as reagents
Pyrimidine derivatives of the formula I STR1 in which R1, R2, X and Y have the stated meaning, the salts thereof and a process for the preparation thereof are described. Because of their sorbitol-accumulating activity, they are suitable for use as reagents for an advantageous pharmacological screening model for testing aldose reductase inhibitors.
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(2008/06/13)
SUBSTITUTED THIENOIMIDAZOLE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THE USE THEREOF AS INHIBITORS OF GASTRIC ACID SECRETION, AS GASTROPROTECTIVES AND AS MEDICAMENTS FOR INTESTINAL INFLAMMATIONS
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(2008/06/13)
Pyrimidylalkylthio benzimidale compounds, pharmaceutical compositions and use
This invention relates to 2- and 4-pyrimidinylmethylsulphinyl(and thio)benzimidazoles in which the pyrimidyl group is substituted by an optionally substituted amino group. These compounds inhibit exogenously and endogenously stimulated gastric acid secretion.
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(2008/06/13)
Preparation and photochemistry of py rimidine nucleoside sulfonium ylides.
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Kunieda,Witkop
p. 3487 - 3493
(2007/10/08)
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