- THIOSUCCINIC ACID DERIVATIVES AND THE USE THEREOF
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The present invention relates to compounds of the formula (I) wherein X1 and X2 independently represent O, NH or S, R1 and R2 are independently selected from the group consisting of a C1-C30 hydrocarbyl group, an amino acid bonded via an amide bond or a peptide bonded via an amide bond each having up to 200 amino acids, the conjugated residue X1 or X2 in this case being NH, and hydrogen, both radicals R1 and R2 preferably not being H, wherein R3 is a residue selected from group consisting of -S-R6, wherein R6 is a C1-C30 hydrocarbyl group, at least one of R1 and R2 not being H when X1 and X2 are oxygen, -S-CH2-CH(NH2)(COOH) (cysteine-S-yl), a homologue or derivative (e.g. N-acetyl cysteine-S-yl) thereof, a peptide having up to 200 amino acids which contains at least one amino acid radical with a thiol group, preferably a cysteine radical, and is bonded via the thio sulfur, preferably via the cysteine sulfur (peptide-S-yl), coenzyme A which is bonded via a thiol troup or fragments thereof, acyl carrier protein bonded via a thiol group, and dihydrolipoic acid bonded via a thiol group, and pharmaceutically acceptable salts thereof. The present invention also relates to the use of these compounds for preparing a drug and drugs containing the same.
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Page/Page column 17-18
(2008/06/13)
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- Oxidation of Thiols and Disulphides with Ammoniumyl Radical-cation, +.NH3: an E.S.R. Investigation
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E.s.r. spectroscopy has been employed to demonstrate that the reaction of +.NH3 (from TiIII and +NH3OH) with thiols (RSH) proceeds via the initial formation of thiyl radicals (RS.); these react further to give disulphides as well as oxygen-containing radicals RSO. and RSO2., formed by a series of one-electron oxidation reactions, and both SO2-. and SO3-. (which arise via sulphur dioxide formed in the decomposition of RSO2.).Reaction with disulphides, which leads to the detection of sulphinyl radicals and disulphide-conjugated radicals, is thought to involve both radical-cations (RSSR+.) and ammoniumyl adducts .(N+H3)SR> whose further reactions have been described.
- Gilbert, Bruce C.,Marriott, Paul R.
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p. 191 - 197
(2007/10/02)
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