Trifluoromethylation of nonenolizable carbonyl compounds with a stable piperazino hemiaminal of trifluoroacetaldehyde
A new stable hemiaminal of fluoral (1) can easily be obtained from the methyl hemiketal of fluoral and N-benzylpiperazine. This white crystalline compound can be used under basic conditions as an efficient nucleophilic trifluoromethylating reagent towards nonenolizable carbonyl compounds.
Billard, Thierry,Langlois, Bernard R.,Blond, Gaelle
New stable reagents for the nucleophilic trifluoromethylation. Part 2: Trifluoromethylation with silylated hemiaminals of trifluoroacetaldehyde
New reagents for the nucleophilic trifluoromethylation have been easily synthesized from fluoral hemiketal. They provide silylated trifluoromethylcarbinol from non-enolizable carbonyl compounds. (C) 2000 Elsevier Science Ltd.
Billard,Langlois,Blond
p. 8777 - 8780
(2007/10/03)
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