CALPAIN-2 INHIBITOR COMPOUNDS AND METHODS OF TREATMENT
Compounds of Formula (I) or (X) are provided including for treatment of disorders such as a disorder or symptom associated with neuronal cell death. In one aspect, compounds which are selective inhibitors of calpain-2 are provided. Preferred compounds can
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(2021/08/20)
CALPAIN-2 SELECTIVE INHIBITOR COMPOUNDS FOR TREATMENT OF GLAUCOMA
Compounds of Formula (I) are provided including for treatment of disorders such as glaucoma.
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(2020/03/05)
Synthesis of proline analogues as potent and selective cathepsin S inhibitors
Cathepsin S is a potential target of autoimmune disease. A series of proline derived compounds were synthesized and evaluated as cathepsin S inhibitors. We discovered potent cathepsin S inhibitors through structure-activity relationship studies of proline analogues. In particular, compound 19-(S) showed promising in vitro/vivo pharmacological activities and properties as a selective cathepsin S inhibitor.
Kim, Mira,Jeon, Jiyoung,Song, Jiyeon,Suh, Kwee Hyun,Kim, Young Hoon,Min, Kyung Hoon,Lee, Kwang-Ok
p. 3140 - 3144
(2013/06/26)
An efficient copper-catalysed pyrrole synthesis
Copper-catalysed cyclisations of β-hydroxyhomopropargylic sulfonamides can be carried out using copper(II) acetate in hot toluene to provide generally excellent yields of the corresponding pyrroles. ARKAT-USA, Inc.
Dunford, Damian G.,Knight, David W.,Wheeler, Robert C.
p. 253 - 273
(2013/01/16)
TRPV3 Modulators
Disclosed herein are modulators of TRPV3 of formula (I) wherein X1, X2, R1, R2, Rx, and n are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
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Page/Page column 54
(2012/10/08)
Novel angular benzophenazines: Dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents
A series of substituted angular benzophenazines were prepared using a new synthetic route via a novel regiocontrolled condensation of 1,2-naphthoquinones and 2,3-diaminobenzoic acids. The synthesis and biological activity of this new series of substituted
Vicker, Nigel,Burgess, Luke,Chuckowree, Irina S.,Dodd, Rory,Folkes, Adrian J.,Hardick, David J.,Hancox, Timothy C.,Miller, Warren,Milton, John,Sohal, Sukhjit,Wang, Shouming,Wren, Stephen P.,Charlton, Peter A.,Dangerfield, Wendy,Liddle, Chris,Mistry, Prakash,Stewart, Alistair J.,Denny, William A.
p. 721 - 739
(2007/10/03)
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