- Based on isoxazole substitution of benzamide derivatives and anti-prostate cancer drug applications
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The present invention discloses a class (I), formula (II) structure based on isoxazole substituted benzamide derivatives and antiprostate cancer drug applications, such isoxazole substituted benzamide derivatives, can effectively inhibit the activity of a
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Paragraph 0065; 0073-0074
(2022/01/10)
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- SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES
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The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.
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Page/Page column 14-15; 40; 59-60
(2019/11/12)
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- 2-ACYLAMINOTHIAZOLES FOR THE TREATMENT OF CANCER
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The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.
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- Convenient and simple synthesis of 2-aminothiazoles by the reaction of α-halo ketone carbonyls with ammonium thiocyanate in the presence of N-methylimidazole
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Substituted 2-aminothiazole derivatives were obtained as a result of N-methylimidazole catalyzed cyclization of α-halo ketone carbonyls with ammonium thiocyanate in water-alcoholic media. The generality of the method has been demonstrated by screening a series of aromatic/heteroaromatic/aliphatic α-halo ketones, α-halo β-diketones, and α-halo β-ketoesters. The developed method is simple, mild, and general route for the preparation of diversely functionalized 2-aminothiazoles in good to moderate yields from readily available starting materials.
- Meshram,Thakur, Pramod B.,Madhu Babu,Bangade, Vikas M.
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p. 5265 - 5269
(2012/10/30)
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- BROMINATION OF 4-(2-THIENYL)THIAZOLES AND 2-(2-THIENYL)QUINOLINE
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Depending on the substituent, the bromination of 4-(2-thienyl)thiazoles and 2-(2-thienyl)quinoline takes place in the 5 position of the thiophene or thiazole ring.When an amino group is present in the 2 position of the thiazole ring, bromination takes place in the 5 position of the thiazole ring.When excess brominating agent is present, a second bromine atom enters the 5 position of the free ring.
- Smirnov, V. A.,Zimichev, A. V.,Lyzhova, G. A.,Lipkin, A. E.
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