- PROCESS FOR THE PREPARATION OF 4-SUBSTITUTED-1-(TRIFLUOROMETHOXY)BENZENE COMPOUNDS
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The present invention provides the process for the preparation of 4-substituted-1- (trifluoromethoxy) benzene compounds..
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Page/Page column 7
(2016/09/22)
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- Production method of trifluoromethoxybenzene
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The invention relates to a production method of an aromatic compound, in particular to a production method of trifluoromethoxybenzene. The production method includes chlorination reaction, fluoridation reaction and product separation and is characterized in that anisole is used as the initial raw material, the chlorination reaction uses aromatic hydrocarbon containing fluorine as the solvent, the solvent cannot be separated after the reaction, the fluoridation reaction of the solvent and HF is performed under proper conditions, the reaction products of the fluoridation reaction are subjected to washing and layering, the lower oil phase is subjected to rectification to obtain the trifluoromethoxybenzene, and the solvent is recycled. The purity of the obtained trifluoromethoxybenzene is larger than 99%, and the yield of the trifluoromethoxybenzene is larger than 95%. The chemical reaction formula is shown as follows.
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Paragraph 0037; 0038; 0039; 0044-0046; 0051-0053; 0058-0060
(2017/04/29)
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- Catalytic halodefluorination of aliphatic carbon-fluorine bonds
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A variety of halosilanes, in conjunction with aluminum catalysts, convert fluorocarbons into higher halocarbons. Bromination and iodination of fluorocarbons are more effective than chlorination in terms of yield and activity. The mechanism for the reaction is investigated utilizing experimental and computational evidence and preliminary results suggest an alternate mechanism to that reported for the related hydrodefluorination reaction.
- Goh, Kelvin K.K.,Sinha, Arup,Fraser, Craig,Young, Rowan D.
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p. 42708 - 42712
(2016/05/19)
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- The reaction of α,α,α-trifluoromethoxybenzene with AlCl3: A high yield preparation of α,α,α-trichloromethoxybenzene
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α,α,α-Trifluoromethoxybenzene was allowed to react with AlCl3 in CH2Cl2 to afford α,α,α-trichloromethoxybenzene in excellent yield and purity.
- Chen, Qiliang,Xu, Jie,Zhang, Wei
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p. 799 - 801
(2007/10/03)
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- Method of making trichloromethoxybenzene
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Disclosed is a method of making trichloromethoxybenzene. A mixture is prepared of anisole and a source of chlorine free radicals, such as chlorine or sulfuryl chloride. The reaction is performed in a solvent, which can be either benzotrifluoride, orthochlorobenzotrifluoride, metachlorobenzotrifluoride, parachlorobenzotrifluoride, or dichlorobenzotrifluoride. The mixture is exposed to actinic radiation, such as ultraviolet light, which generates the chlorine free radicals.
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- Formation of Dichloromethyl Phenyl Ethers as Major Products in Photo-Reimer-Tiemann Reaction without Base
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Photolysis of phenols 1a-d in chloroform or carbon tetrachloride afforded the corresponding di- or trichloromethyl phenyl ethers (2a-d or 6a-d, respectively).In chloroform, hydroxybenzaldehydes 4a-d or 5 and phenyl formates 3a-d were obtained as minor photoproducts.In carbon tetrachloride, traces of salicyloyl chloride (7), phenyl salicylate (8) and phenyl p-hydroxybenzoate (9) were detected starting from the parent phenol (1a).The obtained results agree with the involvement of an electron transfer mechanism.
- Jimenez, M. Consuelo,Miranda, Miguel A.,Tormos, Rosa
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p. 5825 - 5830
(2007/10/02)
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