- A practical synthesis of aryl tetrafluoroethyl ethers via the improved reaction of phenols with 1,2-dibromotetrafluoroethane
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An efficient and practical synthesis of various aryl tetrafluoroethyl ethers by the reaction of phenols with 1,2-dibromotetrafluoroethane and the subsequent reduction with zinc dust was described. The nucleophilic substitution of 1,2-dibromotetrafluoroethane with phenols initiated by bromophilic attack was improved by using Cs2CO3 as a base and DMSO as a solvent.
- Li, Jianqing,Qiao, Jennifer X.,Smith, Daniel,Chen, Bang-Chi,Salvati, Mark E.,Roberge, Jacques Y.,Balasubramanian, Balu N.
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- Nucleophilic difluoroalkylation of benzophenones, benzaldehydes and Schiff's bases by tetrafluoroethyl ether and difluoroacetamide
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From gem-difluoromethyl group of 1,1,2,2-tetrafluoroethyl ether and 2,2-difluoroalkylamide, proton can be removed by potassium bis(trimethylsilyl)amide in DMF, THF or toluene. The generated nucleophiles are then condensed with benzophenones, benzaldehydes or Schiff's bases to provide new fluorinated alcohols and amines. Some interesting solvent effects are also observed.
- Vaidyanathaswamy,Raman, G. Anantha,Ramkumar,Anand, Rajdeep
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- A mild hydrodehalogenation of fluoroalkyl halides
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A mild hydrodehalogenation reaction of fluoroalkyl halides (RfCF2X, X = Br, I) has been developed under weakly basic conditions, giving the corresponding hydrogenolysis products with moderate to high yields.
- Zhang, Cheng-Pan,Chen, Qing-Yun,Xiao, Ji-Chang,Gu, Yu-Cheng
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experimental part
p. 671 - 673
(2009/12/22)
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- Fluorinated arylethers and methods for use thereof
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The invention provides new fluorinated solvents that have many uses. One such use is as a solvent useful in the deposition of organic active materials in the manufacture of organic electronic devices. The new fluorinated solvents are fluorinated arylethers and can be readily prepared from corresponding phenols and fluorinated olefins.
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Page/Page column 4
(2008/06/13)
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- SPONTANEOUS REACTIONS OF POTASSIUM PHENOXIDE WITH DIBROMOPERFLUOROALKANES. FIRST EVIDENCE FOR BROMOPHILIC ATTACK ON C-Br BONDS BY THE PHENOXIDE ION.
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In contrast to earlier reports, It has been found that dibromoperfluoroalkanes actually can react spontaneously with PhOK, yielding fluoroalkyl phenyl ethers as products.Evidence for an anionic chain mechanism involving a bromophilic attack by the phenoxyde ion is presented.
- Xingya, Li,Heqi, Pan,Xikui, Jiang
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p. 4937 - 4940
(2007/10/02)
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- CONDENSATION OF 1,2-DIBROMOTETRAFLUOROETHANE WITH VARIOUS POTASSIUM THIOPHENOXIDES AND PHENOXIDES
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BrCF2CF2Br reacts easily with various potassium thiophenoxides and phenoxides to give respectively 2-bromo tetrafluoroethyl thioethers and ethers.The lipophilicity of C6H5SCF2CF2Br and C6H5OCF2CF2Br is measured and compared with that of the well known C6H5SCF2CF2H and C6H5OCF2CF2H.
- Rico, I.,Wakselman, C.
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p. 759 - 764
(2007/10/02)
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