- Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1] Skeleton Compounds
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A palladium-catalyzed tandem reaction is reported that involves chloropalladation/cyclization and dearomative cyclization to construct a tricyclic bridged [3.2.1] carbocyclic-skeleton and oxa- and aza-skeletons. In this domino process, a level of ring strain and other competitive reactions, i.e., protonolysis, β-hydride elimination, and chlorination of the C-Pd bond, were suppressed to the lowest level under mild reaction conditions.
- Dong, Yi,Du, Nana,Li, Xueyuan,Zheng, Litao,Liu, Gang
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supporting information
p. 4110 - 4113
(2015/09/01)
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- Benzothiazines in synthesis. Eight-membered ring formation in an intramolecular Friedel-Crafts reaction
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Treatment of certain benzothiazines bearing allylic bromides side chains with indium tribromide resulted in the formation of eight-membered rings in addition to the expected six-membered rings.
- Harmata, Michael,Ying, Weijiang,Barnes, Charles L.
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supporting information; experimental part
p. 2326 - 2328
(2009/08/17)
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- NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS
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Novel heterocyclic compounds are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agent. Method of synthesis and use of such compounds are also described.
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Page/Page column 312
(2008/06/13)
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