Difurocoumarins: Psoralen analogs as photochemotherapeutic agents
New tetracyclic psoralen-like compounds have been synthesized, which are characterized by two furan rings angularly condensed on the coumarin nucleus and are therefore called difurocoumarins. This structural feature may favour the intercalation into the D
5,7-Dihydroxy-4-methyl- and 5,7-dihydroxy-4-trifluoromethylcoumarins are starting compounds in the synthesis of new 10-methyl-8H-difuro[2,3-f;2,3-h]-8- ones and 10-trifluoromethyl-8H-difuro[2,3-f;2,3-h]chromen-8-ones with high yields.