A synthesis of atenolol using a nitrile hydration catalyst
The synthesis of atenolol is described using a platinum containing homogeneous catalyst for the conversion of a nitrile to an amide. The catalytic reaction may be employed as the final step in the synthesis or in the preparation of the intermediate 4-hydroxyphenylacetamide. The structure of the nitrile intermediate, 1-(4′-cyanomethylphenoxy)-2-hydroxy-3-isopropylaminopropane, has been determined by X-ray crystallography.
Akisanya, Joseph,Parkins, Adrian W.,Steed, Jonathan W.
p. 274 - 276
(2013/09/08)
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