cas 35410-28-7, 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate | Articles data ｜lookchem

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35410-28-7

Articles about 35410-28-7Total 3 be found

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Synthesis of novel anti-inflammatory steroidal macrocycles using ring closing metathesis reaction
A novel class of 13 and 16 membered steroidal macrocycles were synthesized by using ring closing metathesis reaction from the readily available anti-inflammatory steroids such as prednisolone, 6-methyl prednisolone, and 16-methyl prednisolone.
Biju, Purakkattle,Bitar, Rema,Lim, Yeon-Hee,Wang, Ying,Berlin, Michael,Aslanian, Robert,McCormick, Kevin
p. 636 - 638
(2015)
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SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 21-ESTERS OF PREDNISOLONE WITH GLYCINE AND GLUTAMIC ACID
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Ryakhovskaya, M. I.,Grinenko, G. S.,Alekseeva, L. M.,Engalycheva, G. N.,Nikitin, V. B.,et al.
p. 235 - 238
(1991)
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Steroidal C-21 mercapto derivatives as dissociated steroids: Discovery of an inhaled dissociated steroid
A series of C-21 mercapto derivatives of hydrocortisone have been synthesized and evaluated in cell based transrepression and transactivation assays. The benzothiazole derivative, compound 6 not only showed a dissociated profile in vitro functional assays but also a pharmacological profile in a Brown-Norway rat therapeutic index model of asthma that dissociated side effects (thymolysis) while maintaining efficacy against pulmonary inflammation and lung function.
Biju, Purakkattle,McCormick, Kevin,Aslanian, Robert,Berlin, Michael,Solomon, Daniel,Chapman, Richard,McLeod, Robbie,Prelusky, Daniel,Eckel, Stephen,Kelly, George,Natiello, Michelle,House, Aileen,Fernandez, Xiomara,Bitar, Rema,Phillips, Jonathan,Anthes, John
scheme or table
p. 6343 - 6347
(2011/12/02)

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Chemical Properties

Boiling Point: 656.1°Cat760mmHg
Flash Point:350.6°C
Density: 1.37g/cm³
Vapor Pressure: 5.36E-20mmHg at 25°C
PSA: 126.35000
LogP: 2.62230

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