- Electrochemical Oxidation of Alcohols and Aldehydes to Carboxylic Acids Catalyzed by 4-Acetamido-TEMPO: An Alternative to "anelli" and "pinnick" Oxidations
-
An electrocatalytic method has been developed to oxidize primary alcohols and aldehydes to the corresponding carboxylic acids using 4-acetamido-2,2,6,6-tetramethylpiperidin-1-oxyl (ACT) as a mediator. The method successfully converts benzylic, aliphatic, heterocyclic, and other heteroatom-containing substrates to the corresponding carboxylic acids in aqueous solution at room temperature. The mild conditions enable retention of stereochemistry adjacent to the site of oxidation, as demonstrated in a 40 g-scale synthesis of a precursor to levetiracetam, a medication used to treat epilepsy.
- Rafiee, Mohammad,Konz, Zachary M.,Graaf, Matthew D.,Koolman, Hannes F.,Stahl, Shannon S.
-
p. 6738 - 6744
(2018/06/19)
-
- One-step direct conversion of heterocyelie aldehydes to esters
-
One-step direct conversion of a series of heteroeyelie aldehydes to heterocyclie esters is reported here by the use of thiamine hydrochloride as a catalyst in the absence of nitrogen atmosphere in a reasonably high yield. This method exclusively produces
- Goswami, Shyamaprosad,Hazra, Anita
-
supporting information; experimental part
p. 484 - 485
(2010/03/04)
-