- A Diselenide Turn-On Fluorescent Probe for the Detection of Thioredoxin Reductase
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We report the first diselenide-based probe for the selective detection of thioredoxin reductase (TrxR), an enzyme commonly overexpressed in melanomas. The probe design involves conjugation of a seminaphthorhodafluor dye with a diselenide moiety. TrxR redu
- Bassett, John W.,Cassidy, Pamela B.,Escobedo, Jorge O.,Laws, Madeleine,Mafireyi, Tendai J.,Strongin, Robert M.
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supporting information
p. 15147 - 15151
(2020/07/02)
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- Investigation of the hydrogen bond donating ability of 1,8-naphthalenediol by NMR spectroscopy and its use as a hydrogen bonding catalyst
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The hydrogen bond donating ability of 1,8-naphthalenediol was investigated via a series of 1H, 13C, and 31P NMR experiments. Complexation studies using triphenylphosphine oxide and cyclohexanone as hydrogen bond acceptors
- Turkmen, Yunus Emre
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p. 1398 - 1407
(2018/10/23)
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- MOLECULAR PROBES FOR DETECTION AND IMAGING OF PANCREATIC CANCER
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Molecular probes for detecting and imaging pancreatic cancer are disclosed. The probes are modified benzoxanthene fluorophores, which are selectively taken up by pancreatic cancer cells, such as pancreatic ductal adenocarcinoma cells. Embodiments of the disclosed probes are useful for pancreatic cancer detection, therapeutic monitoring, and/or image-guided surgery.
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Page/Page column 21
(2017/12/29)
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- SYNTHESIS OF THE POTENT IMMUNOSUPPRESSANT AGENTS DALESCONOL A AND B
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This invention relates to compounds having the structure: wherein bonds α, β, γ, δ, ω, η, χ, ε, κ, and μ are each present or absent, and R1-R18 are various substituents described herein.
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- A concise approach to the dalesconol skeleton
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A rapid approach to the skeleton of dalesconol A and B, unprecedented immunosuppressants, has been achieved through a convergent strategy featuring a carbocation-mediated dearomatization-cyclization and a following one-pot consecutive operation.
- Fan, Yukai,Feng, Pengju,Liu, Mao,Pan, Hongjie,Shi, Yian
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p. 4494 - 4497
(2011/10/11)
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- Transformation of 5-methoxy-1-tetralone into 8-methoxy-1-tetralone
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The transformation of 1-hydroxy-5-methoxtetralin into 4-hydroxy-8-methoxy- 1-tetralone was accomplished in three steps (benzoylation, oxidation and alkaline hydrolysis). Treatment of the corresponding ketotosylate with sodium iodide and zinc dust in dimet
- Banerjee, Ajoy K.,Bedoya, Liadis,Adherian, Maria E.,Vera, William J.,Cabrera, Elvia V.,Kariney, Elidig R.
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experimental part
p. 522 - 524
(2010/12/25)
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- Total syntheses of dalesconol A and B
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(Chemical equation Presented) (Chemical equation Presented) A polycyclic collapse: Use of a carefully designed acyclic intermediate participated in a cascade reaction that formed the entire core of the polyketide-derived dalesconols in a single flask (see scheme). A number of additional and carefully controlled synthetic operations completed an expeditious synthesis of both of these highly bioactive natural products as well as structural congenors.
- Snyder, Scott A.,Sherwood, Trevor C.,Ross, Audrey G.
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supporting information; experimental part
p. 5146 - 5150
(2010/11/04)
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- Synthesis of substituted (S)-2-aminotetralins via ring-opening of aziridines prepared from l-aspartic acid β-tert-butyl ester
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This paper describes the total synthesis of the hydrochloride salts of (2S)-2-amino-7-methoxytetralin (21-HCl) and (2S)-2-amino-6-fluoro-7- methoxytetralin (ST1214), from a common enantiomerically pure aziridine 4b, which was available from l-aspartic acid β-tert-butyl ester. The synthesis of 21-HCl and ST1214 proceeded in nine steps and 5 and 6% overall yields, respectively. Key steps are the regioselective ring-opening of 4b with ArMgBr/CuBr·SMe2 and the intramolecular Friedel-Crafts cyclisation providing α-tetralone. Substituted naphthalenes were formed as side products in the latter reaction.
- Aaseng, Jon Erik,Gautun, Odd R.
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experimental part
p. 8982 - 8991
(2011/01/04)
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- Isomerization of 7-oxabenzonorbornadienes into naphthols catalyzed by [RuCl2(CO)3]2
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(Chemical Equation Presented) Ruthenium-catalyzed isomerization of 7-oxanorbornadienes into naphthols was investigated. Among the various ruthenium catalysts tested, [RuCl2(CO)3]2 gave the highest yields in the isomerizati
- Ballantine, Melissa,Menard, Michelle L.,Tam, William
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supporting information; experimental part
p. 7570 - 7573
(2009/12/28)
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- Anionic Aromatic Ring Annelation of o-Allylbenzamides. Regiospecific Synthesis of Naphthols and Naphthoquinones
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o-Allylbenzamides 2, available from 1 by directed ortho methalation or transition metal catalyzed cross-coupling reactions, undergo MeLi-induced cyclization to give 1-naphthols 3, some of which are immediate precursors for oxygenated naphthoquinones 6 and 7
- Sibi, M.P.,Dankwardt, J.W.,Snieckus, V.
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p. 271 - 273
(2007/10/02)
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