- Method for preparing hydrocarbyl phenol by catalytic conversion of phenolic compound in presence of molybdenum-based catalyst
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The invention discloses a method for preparing hydrocarbyl phenol by catalytic conversion of a phenolic compound in the presence of a molybdenum-based catalyst. The method comprises mixing a phenoliccompound, a molybdenum-based catalyst and a reaction solvent, adding the mixture into a sealed reactor, feeding gas into the reactor, heating the mixture to 150-350 DEG C, carrying out stirring for areaction for 0.5-2h, then filtering to remove a solid catalyst and carrying out rotary evaporateion to obtain a liquid product. The phenolic compound has a wide source, a cost is low, product alkyl phenol selectivity is high, an added value is high, alcohol or an alcohol-water mixture is used as a reaction solvent, environmental friendliness is realized, pollution is avoided, any inorganic acids and alkalis are avoided in the reaction process, the common environmental pollution problems in the biomass processing technology are solved, the reaction conditions are mild, the process can be carried out at a low temperature, high-efficiency conversion of the reactants can be realized without consuming hydrogen gas and the method is suitable for large-scale industrial trial production.
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Paragraph 0043-0044; 0070
(2018/04/02)
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- 2,5-DIALKYL-4-H/HALO/ETHER-PHENOL COMPOUNDS
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The present disclosure provides phenolic compounds useful in the treatment of neurological conditions such as convulsions and tremors, having the structure of Formula (I): wherein R2, R4, R5, and R6, are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating neurological conditions.
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- 2,5-DIALKYL-4-H/HALO/ETHER-PHENOL COMPOUNDS
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The present disclosure provides phenolic compounds useful in the treatment of neurological conditions such as convulsions and tremors, having the structure of Formula (I): wherein R2, R4, and R5, are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating neurological conditions.
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- C-H Functionalization at Sterically Congested Positions by the Platinum-Catalyzed Borylation of Arenes
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Despite significant progress in the area of C-H bond functionalization of arenes, no general method has been reported for the functionalization of C-H bonds at the sterically encumbered positions of simple arenes, such as mesitylene. Herein, we report the development of the first platinum-based catalyst for C-H borylation of arenes and heteroarenes. Notably, this method exhibited high tolerance toward steric hindrance and provided rapid access to a series of 2,6-disubstituted phenylboronic esters, valuable building blocks for further elaborations.
- Furukawa, Takayuki,Tobisu, Mamoru,Chatani, Naoto
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p. 12211 - 12214
(2015/10/12)
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- The reaction of nitrile oxide-quinone cycloadducts. III. Reinvestigation of the base-induced isomerization of the 1:1 -C=C-adducts of aromatic nitrile oxides with 2,5-and 2,6-dialkyl-substituted p-benzoquinones
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The structure of the product obtained by the base, induced isomerization of the 1,3-dipolar cycloadduct of 2,5-di-t-butyl-p-benzoquinone with 2,6- dichlorobenzonitrile oxide was determined by X-ray analysis. The t-butyl group at the bridgehead position of the 1,3-dipolar cycloadduct migrated to the neighboring carbonyl carbon atom. This base-induced rearrangement took place with a bulky group, i.e., Et, i-Pr, t-Bu, and Bn at the bridgehead position of nitrile oxide-quinone cycloadducts in an alcoholic media. The driving force of this reaction is considered to be due to stabilization by aromatization from isoxazoline derivatives to isoxazole-fused p-quinol derivatives.
- Mukawa, Takashi,Inoue, Yukihiko,Shiraishi, Shinsaku
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p. 2549 - 2556
(2007/10/03)
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- Alumina-Catalyzed Reactions of Hydroxyarenes and Hydroaromatic Ketones. 10. Reaction of Phenol with 2-Propanol
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At 300-350 deg C in the presence of alumina, phenol (1) reacts with excess 2-propanol (37) to give mixed monopropyl-, dipropyl-, and 2,4,6-triisopropyl- (42) phenols. At 300 deg C the principal components of the product mixture are 2-isopropylphenol (26-30 mol percent yield) and 2,6-diisopropylphenol (44-52percent); at 350-400 deg C , they are the isomeric monoisopropylphenols (50-60percent). With 3-isopropylphenol as substrate (instead of 1), 2,5-diisopropylphenol is obtained (79percent), while 4-isopropylphenol gives 2,4-diisopropylphenol and 42 (70percent combined yield). In various runs, 0-20percent of the propyl groups introduced are n-propyl ones. It is proposed that the principal products result from an SN2-type reaction mechanism which involves nucleophilic attack (variously by C-2, C-4, and C-6) of an adsorbed ambident phenoxide ion onto C-2 of an adsorbed isopropoxide group. n-Propylation is ascribed to a side reaction of SN1 type.
- Klemm, LeRoy H.,Taylor, Dennis R.
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p. 4326 - 4329
(2007/10/02)
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