Solvolytically DMSO-promoted reactions of 1,1,1-trifluoroethyl chloride (HCFC-133a) or fluoride (HFC-134a) with nucleophiles
Fluorinated gases HCFC-133a (CF3CH2Cl, bp=6°C) and HFC-134a (CF3CH2F, bp=-27°C) are found highly soluble in DMSO. In their DMSO solutions, oxygen-, nitrogen- and sulfur-nucleophilic reactions may occur in normal
Wu, Kai,Chen, Qing-Yun
p. 4077 - 4084
(2007/10/03)
Synthesis of trifluoroethyl ethers from 2,2,2-trifluoroethyl chloride (HCFC-133a) in high temperature aqueous medium
Treatment of 2,2,2-trifluoroethyl chloride (HCFC-133a) with alcohols (phenols) and aqueous KOH in autoclave at 240-280 C gives the corresponding 2,2,2-trifluoroethyl (2-chloro-1,1-difluoroethyl) ethers in good yields.