- Novel process for preparing isoindoline derivatives
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A process for the preparation of an isoindoline derivative of the following general formula (II): STR1 wherein R2 is a hydrogen atom or lower alkyl group and X is a carboxyl group, carboalkoxy group, amide group or cyano group, which comprises cycling a benzylidene derivative of the following general formula (I) STR2 wherein R1 is a hydrogen atom or lower alkyl group, and R2 and X are as defined above, in the presence of a reducing agent such as sodium boron hydride. In one embodiment, the benzylidene derivative may be substituted by a reaction mixture containing the same, the reaction mixture being prepared by reacting o-phthalaldehydic acid or its ester with an aniline derivative.
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- Isoindoline derivatives for treating pain
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Isoindoline derivatives are disclosed, as for instance of the formula: STR1 and methods of preparation of these compounds, such as the reaction of o-cyano-benzylbromide with a compound of formula STR2 and subsequent saponification. The compounds possess analgesic and anti-inflammatory activity.
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- Tertiary aminoacids
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New α-(cyclic tert. aminophenyl)-aliphatic acids, e.g. those of the formula STR1 AND FUNCTIONAL DERIVATIVES THEREOF, ARE ANTI-INFLAMMATORY AGENTS.
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