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36865-40-4

Articles about 36865-40-4Total 3 be found

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Watanabe,N. et al.
p. 3205 - 3209
(1975)
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Optimization of anti-virulence PqsR antagonists regarding aqueous solubility and biological properties resulting in new insights in structure-activity relationships
Increasing antibiotic resistance urgently requires novel therapeutic options to combat bacterial infections. The anti-virulence therapy selectively intervening with pathogenicity without affecting bacterial viability is such a strategy to overcome resistance. We consider the virulence regulator PqsR as an attractive target in the human pathogen Pseudomonas aeruginosa, and recently discovered the first PqsR antagonists, which, however, suffered from poor aqueous solubility. In this work, the antagonists were structurally modified to become more soluble, and their structure-activity as well as structure-property relationships were studied. A novel promising compound with improved solubility and enhanced anti-virulence activity was discovered (IC50: 3.8 μM, pyocyanin). Our findings emphasize the crucial role of substituents at the 3-position and the carbonyl group at the 4-position for ligand-receptor interactions, and illuminate the way for further optimization of PqsR antagonists as anti-virulence agents.
Lu, Cenbin,Kirsch, Benjamin,Maurer, Christine K.,De Jong, Johannes C.,Braunshausen, Andrea,Steinbach, Anke,Hartmann, Rolf W.
p. 173 - 183
(2014)
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Carbonic anhydrase inhibitors
Compounds of the following formula are disclosed: Compounds of Formula I are the topic of this invention: STR1 Wherein G, J and the two atoms of the thiophene ring to which they are attached form a six-membered ring chosen from STR2 The compounds are usef
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(2008/06/13)

Optically active alcohol, process for producing same and liquid crystal compound using same
A liquid crystal compound represented by formula (II) STR1 wherein R denotes a linear alkyl group having 6 to 14 carbon atoms, X denotes a single bond or an oxygen atom, K and L are independently 1 or 2, m is an integer of 5 to 7, n is an integer of 1 to
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(2008/06/13)

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Chemical Properties

Boiling Point: 129.7 °C at 760 mmHg
Flash Point:44.3 °C
Density: 1.278 g/cm³
Vapor Pressure: 12.3mmHg at 25°C
Refractive Index: 1.443
PSA: 9.23000
LogP: 1.80790

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