Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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(2008/06/13)
NATURE OF THE REDUCING AGENT AND MECHANISM OF THE REDUCTIVE CONDENSATION OF TRICHLOROMETHYLARENES WITH HYDROXYLAMINE AND HYDRAZINES IN PYRIDINE
It was shown that during the reductive condensation of trichloromethylarenes with hydroxylamine or hydrazines in pyridine the event of reduction with replacement of one chlorine atom by a hydrogen atom occurs without the participation of hydroxylamine or hydrazine.The first step of the reaction is the formation of N-(α,α-dichloroarylmethyl)pyridinium chlorides, which are converted by the action of the chloride anion or a second pyridine molecule to the corresponding 4-substituted 1,4-dihydropyridines.The latter undergo further aromatization with transfer of hydrogen from the 4-position of the dihydropyridine ring to the benzyl dichloromethylene group and the formation of N-(α-chloroarylmethyl)-4-chloropyridinium chlorides or N-(α-chloroarylmethyl)-4-(pyridino)pyridinium dichlorides, which give the corresponding aldehydes in hydrolysis or products of reductive condensation under the action of hydroxylamine or hydrazines.
Belen'kii, L. I.,Poddubnyi, I. S.,Krayushin, M. M.
p. 726 - 736
(2007/10/03)
Site-Selectivity in the Reaction of 3-Substituted Pyridine 1-Oxides with Phosphoryl Chloride
Site-selectivity in the reaction of 3-substituted pyridine 1-oxide with phosphoryl chloride was investigated.When a strongly electron-withdrawing group (e.g.CN, CONRR', COOR, or NO2) was substituted at the 3-position, the reaction of 3-substituted pyridine 1-oxides with phosphoryl chloride yielded 3-substituted 2-chloropyridines as the main products.Keywords- site-selectivity; 3-substituted pyridine 1-oxide; phosphoryl chloride; 3-substituted 2-chloropyridine; chlorination
Yamanaka, Hiroshi,Araki, Tomio,Sakamoto, Takao
p. 2244 - 2247
(2007/10/02)
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