- ANTIVIRAL PYRIDOPYRAZINEDIONE COMPOUNDS
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The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.
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Paragraph 0736-0737
(2020/04/09)
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- BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF
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The invention provides novel compounds having the general formula (I): (I) wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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- PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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This document discloses molecules having the following formula (“Formula One”): and processes related thereto.
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Paragraph 0451; 0452
(2016/05/02)
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- TRI-HETEROCYCLIC DERIVATIVES, PREPARATION PROCESS AND USES THEREOF
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The present invention relates to a tri-heterocyclic derivatives, preparation process and uses thereof, specifically relates to a tri-heterocyclic derivatives of the formula (I) or a pharmaceutically acceptable salt thereof, preparation process, and further relates to a pharmaceutically acceptable composition comprising compounds of formula (I), or a pharmaceutically acceptable salt thereof, and their pharmaceutical use as inhibitors of kinase.
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- PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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This document discloses molecules having the following formula (“Formula One”): and processes related thereto.
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Paragraph 0400; 0401
(2013/05/09)
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- PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
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This document discloses molecules having the following formula (“Formula One”): and processes related thereto.
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Paragraph 0450-0451
(2013/11/06)
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- [1,2,4]TRIAZOLOPYRIDINES AND THEIR USE AS PHOSPODIESTERASE INHIBITORS
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The present invention relates to novel [1,2,4]triazolopyridine compounds with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.
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Page/Page column 15
(2013/07/05)
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- NOVEL HETEROARYL-AMINO DERIVATIVES
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Disclosed is a compound of formula (I), wherein R1, R2, L, Rm and Rn are as defined herein. The compound of formula (I) may be used in preventing and/or treating acyl CoA-diacylglycerol acyltransferase 1(DGAT-1) related diseases, such as obesity, coronary disease, hypertension, hyperlipidemia, arteriosclerosis, type II diabetes, stroke, hepatitis C, and the like.
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Page/Page column 39
(2013/05/09)
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- TRI-HETEROCYCLIC DERIVATIVES, PREPARATION PROCESS AND USES THEREOF
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The present invention relates to a tri-heterocyclic derivatives, preparation process and uses thereof, specifically relates to a tri-heterocyclic derivatives of the formula (I) or a pharmaceutically acceptable salt thereof, preparation process, and further relates to a pharmaceutically acceptable composition comprising compounds of formula (I), or a pharmaceutically acceptable salt thereof, and their pharmaceutical use as inhibitors of kinase
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- Pesticidal Compositions and Processes Related Thereto
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This document discloses molecules having the following formula (“Formula One”): and processes related thereto.
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Page/Page column 38
(2012/05/07)
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- PESTICIDAL COMPOSITIONS
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Molecules according to Formula One: and their uses are disclosed herein.
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Paragraph 0170; 0171
(2013/03/26)
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- S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS
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The invention provides novel spirochroman compounds of Formulas I and II that inhibit β-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
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Page/Page column 98-101
(2011/06/26)
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- Compounds Which Selectively Modulate The CB2 Receptor
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Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally usefu
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Page/Page column 55
(2010/04/23)
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- 1-Aminoxymethylcyclopropanecarboxylic acid as building block of β N-O turn and helix: Synthesis and conformational analysis in solution and in the solid state
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Cyclopropane side-chained β2,2-aminoxy oligopeptides were synthesized and conformationally studied. β N-O turn in solution and β N-O helix in the solid state was characterized by 1H NMR, 2D NOESY and FT-IR as well as X-ray crystallography studies. Almost no changes has been observed with the disturbance at α carbon bond angle compared with dimethyl substituted one. This study provided the opportunity to design the bioactive peptidomimetics in a more elaborate way.
- Chang, Xiao-Wei,Han, Qing-Chuan,Jiao, Zhi-Gang,Weng, Lin-Hong,Zhang, Dan-Wei
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p. 9733 - 9737
(2011/02/25)
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- Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
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The synthesis and SAR of a series of arylsulfonylpiperazine inhibitors of 11β-HSD1 are described. Optimization rapidly led to potent, selective, and orally bioavailable inhibitors demonstrating efficacy in a cynomolgus monkey ex vivo enzyme inhibition model.
- Sun, Daqing,Wang, Zhulun,Cardozo, Mario,Choi, Rebekah,DeGraffenreid, Michael,Di, Yongmei,He, Xiao,Jaen, Juan C.,Labelle, Marc,Liu, Jinsong,Ma, Ji,Miao, Shichang,Sudom, Athena,Tang, Liang,Tu, Hua,Ursu, Stefania,Walker, Nigel,Yan, Xuelei,Ye, Qiuping,Powers, Jay P.
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scheme or table
p. 1522 - 1527
(2009/12/07)
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- Spiro derivatives as lipoxygenase inhibitors
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The present invention is concerned with certain novel spiro substituted heterocylic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenases. They may also be useful
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Page/Page column 65
(2008/06/13)
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- Substituted arylpyrazoles
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This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
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Page/Page column 82
(2008/06/13)
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- New methods for the selective reduction of disubstituted malonates to the corresponding hydroxy-ester derivatives
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The reduction of alkylphenylmalonates and dialkylmalonates with LiAl(O- t-Bu)3H proceeds with selective reduction of one of the ester functionalities to provide the hydroxy-ester derivatives in good yields.
- Ayers, Timothy A.
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p. 5467 - 5470
(2007/10/03)
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