- Method for preparing amine through catalytic reduction of nitro compound by cyclic (alkyl) (amino) carbene chromium complex
-
The cyclic (alkyl) (amino) carbene chromium complex is prepared from corresponding ligand salt, alkali and CrCl3 and used for catalyzing pinacol borane to reduce nitro compounds in an ether solvent under mild conditions to generate corresponding amine. The method for preparing amine has the advantages of cheap and accessible raw materials, mild reaction conditions, wide substrate application range, high selectivity and the like, and is simple to operate.
- -
-
Paragraph 0015
(2021/04/17)
-
- Direct Conversion of Hydrazones to Amines using Transaminases
-
Transaminase enzymes (TAms) have been widely used for the amination of aldehydes and ketones, often resulting in optically pure products. In this work, transaminases were directly reacted with hydrazones in a novel approach to form amine products. Several substrates were investigated, including those with furan and phenyl moieties. It was determined that the amine yields increased when an additional electrophile was added to the reaction mixture, suggesting that they can sequester the hydrazine released in the reaction. Pyridoxal 5’-phosphate (PLP), a cofactor for transaminases, and polyethylene glycol (PEG)-aldehydes were both found to increase the yield of amine formed. Notably, the amination of (S)-(?)-1-amino-2-(methoxymethyl)pyrrolidine (SAMP) hydrazones gave promising results as a method to form chiral β-substituted amines in good yield.
- Carter, Eve M.,Hailes, Helen C.,Sheppard, Tom D.,Subrizi, Fabiana,Ward, John M.
-
p. 4520 - 4523
(2021/09/20)
-
- Organogermanium(II) Hydrides as a Source of Highly Soluble LiH
-
The reactions of monomeric C,N-chelated organogermanium(II) hydride L(H)Ge?BH3 with organolithium salts RLi yielded lithium hydrogermanatoborates (Li(THF)2{BH3[L(H)GeR]})2. Compound (Li(THF)2{BH3[L(H)GePh]})2 was used as a source of LiH for the reduction of organic C=O or C=N bonds in nonpolar solvents accompanied by the elimination of a neutral complex L(Ph)Ge?BH3. The interaction of (Li(THF)2{BH3[L(H)GePh]})2 with the polar C=O bond was further investigated by computational studies revealing a plausible geometry of a pre-reactive intermediate. The experimental and theoretical studies suggest that, although the Li atom of (Li(THF)2{BH3[L(H)GePh]})2 coordinates the C=O bond, the GeH fragment is the active species in the reduction reaction. Finally, benzaldehyde was reduced by a mixture of L(H)Ge?BH3 with PhLi in nonpolar solvents.
- Deraet, Xavier,Dostál, Libor,Jambor, Roman,R??i?ka, Ale?,Tremmel, Jakub,Turek, Jan,Tydlitát, Ji?í
-
supporting information
(2020/05/08)
-
- Half-sandwiched ruthenium complex containing carborane schiff base ligand and preparation and application thereof
-
The invention relates to a half-sandwiched ruthenium complex containing a carborane schiff base ligand and a preparation and an application thereof. The preparation method specifically comprises the following steps; i) dissolving o-carborane formaldehyde and aromatic amine in an organic solvent, carrying out reaction at 60-100 DEG C for 8-12h, cooling to room temperature after the reaction; ii) adding n-butyllithium, carrying out reaction at room temperature for 1.5-2.5h; ii) adding phellandrene ruthenium chloride dimer, carrying out reaction at room temperature for 3-6h, and obtaining the half-sandwiched ruthenium complex through separation. The half-sandwiched ruthenium complex is applied to catalyze transfer hydrogenation reaction of nitrile compounds. Compared with the prior art, the complex of the present invention is not sensitive to air and water, has stable properties, and shows high-efficiency catalytic activity in catalyzing the transfer hydrogenation reaction of nitrile compounds. The preparation method of the complex is simple and green, high in yield, mild in reaction conditions and good in universality.
- -
-
Paragraph 0067-0071
(2020/12/09)
-
- A State-of-the-Art Heterogeneous Catalyst for Efficient and General Nitrile Hydrogenation
-
Cobalt-doped hybrid materials consisting of metal oxides and carbon derived from chitin were prepared, characterized and tested for industrially relevant nitrile hydrogenations. The optimal catalyst supported onto MgO showed, after pyrolysis at 700 °C, magnesium oxide nanocubes decorated with carbon-enveloped Co nanoparticles. This special structure allows for the selective hydrogenation of diverse and demanding nitriles to the corresponding primary amines under mild conditions (e.g. 70 °C, 20 bar H2). The advantage of this novel catalytic material is showcased for industrially important substrates, including adipodinitrile, picolinonitrile, and fatty acid nitriles. Notably, the developed system outperformed all other tested commercial catalysts, for example, Raney Nickel and even noble-metal-based systems in these transformations.
- Formenti, Dario,Mocci, Rita,Atia, Hanan,Dastgir, Sarim,Anwar, Muhammad,Bachmann, Stephan,Scalone, Michelangelo,Junge, Kathrin,Beller, Matthias
-
supporting information
p. 15589 - 15595
(2020/10/02)
-
- Metal-free nitrogen -doped carbon nanosheets: A catalyst for the direct synthesis of imines under mild conditions
-
Herein, a highly stable, porous, multifunctional and metal-free catalyst was developed, which exhibited significant catalytic performance in the oxidation of amines and transfer hydrogenation of nitriles under mild conditions; this could be attributed to the presence of numerous active sites and their outstanding BET surface area. The obtained results showed that most of the yields of imines exceeded 90%, and the cycling performance of the catalyst could be at least seven runs without any decay in the reaction activity, which could be comparable to those of metal catalysts. Subsequently, a kinetic study has demonstrated that the apparent activation energy for the direct synthesis of imines from amines is 67.39 kJ mol-1, which has been performed to testify that the catalytic performances are rational. Via catalyst characterizations and experimental data, graphitic-N has been proven to be the active site of the catalyst. Hence, this study is beneficial to comprehend the mechanism of action of a metal-free N-doped carbon catalyst in the formation of imines.
- Wang, Kaizhi,Jiang, Pengbo,Yang, Ming,Ma, Ping,Qin, Jiaheng,Huang, Xiaokang,Ma, Lei,Li, Rong
-
p. 2448 - 2461
(2019/05/17)
-
- Method for synthesizing methylaminopyridine compound by one-step method
-
The invention discloses a method for synthesizing a methylaminopyridine compound by a one-step method. The method comprises the following steps: with cyanopyridine as a raw material, methanol as a reaction solvent and a palladium-carbon catalyst as a catalyst, performing nitrogen replacement, and carrying out a reaction for 4-10 hours in an ammonia atmosphere under the conditions that the hydrogenpressure is 0.5-2.0 MPa and the temperature is 15-30 DEG C; cooling the reaction product to room temperature, filtering the reaction product, recovering filter residues for later use, and performingreduced pressure distillation on the filtrate, thereby obtaining the product methylaminopyridine compound. The method provided by the invention has the advantages of mild reaction conditions, simple steps, convenient product separation and purification, few side reactions, high yield and the like, the purity of the final product is higher than 99.9%, and the catalyst filtered and recovered after the reaction and the distilled reaction solvent can be recycled, so that the problems of low yield, high cost and the like in the prior art are solved.
- -
-
Paragraph 0023-0026
(2020/01/04)
-
- Cyclopentadienyl-Ru(II)-Pyridylamine Complexes: Synthesis, X-ray Structure, and Application in Catalytic Transformation of Bio-Derived Furans to Levulinic Acid and Diketones in Water
-
A series of cationic half-sandwich cyclopentadienyl-ruthenium(II)-pyridylamine complexes, [(η5-C5H5)Ru(κ2-L)(PPh3)]+ (L = Namine-substituted pyridylamine ligands) ([Ru]-1-[Ru]-6), along with the analogous cyclopentadienyl-ruthenium(II)-N-isopropylpyridylimine complex [(η5-C5H5)Ru(κ2-L)(PPh3)]+ (L = N-isopropylpyridylimine) ([Ru]-7), have been synthesized in good yields. Structural identities of all the complexes have been authenticated by 1H, 13C, and 31P NMR, mass spectrometry, and X-ray crystallography. The synthesized complexes exhibited high catalytic activity for the transformation of the bio-derived furans, 2-furfural (furfural), 5-methyl-2-furfural (5-MF), and 5-hydroxymethyl-2-furfural (5-HMF) to levulinic acid (LA) and the diketones, 3-hydroxyhexane-2,5-dione (3-HHD), 1-hydroxyhexane-2,5-dione (1-HHD), and hexane-2,5-dione (HD) in water. Efficient transformation of furfural to LA over a range of η5-Cp-Ru-pyridylamine complexes is substantially affected by the Namine-substituents, where a η5-Cp-Ru-N-propylpyridylamine complex ([Ru]-2) exhibited higher catalytic activity in comparison to other η5-Cp-Ru-pyridylamine and η5-Cp-Ru-pyridylimine complexes. The relative catalytic activity of the studied complexes demonstrated a substantial structure-activity relationship which is governed by the basicity of Namine, steric hindrance at Namine, and the hemilabile nature of the coordinated pyridylamine ligands.
- Dwivedi, Ambikesh D.,Sahu, Vinod K.,Mobin, Shaikh M.,Singh, Sanjay K.
-
supporting information
p. 4777 - 4787
(2018/04/25)
-
- Direct Catalytic Hydrogenation of Simple Amides: A Highly Efficient Approach from Amides to Amines and Alcohols
-
A highly chemoselective and reactive direct catalytic reduction of various amides to amines and alcohols was developed by using a tetradentate ruthenium complex. The catalytic system showed excellent activity (turnover numbers up to 19 600) and great functional group tolerance under mild reaction conditions, compared to several bidentate and tridentate ruthenium-catalyzed systems.
- Shi, Liyang,Tan, Xuefeng,Long, Jiao,Xiong, Xiong,Yang, Song,Xue, Peng,Lv, Hui,Zhang, Xumu
-
supporting information
p. 546 - 548
(2017/01/18)
-
- HIV INTEGRASE INHIBITORS
-
The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
- -
-
-
- Synthesis of a yolk/shell Fe3O4@poly(ionic liquid)s-derived nitrogen doped graphitic porous carbon materials and its application as support for nickel catalysts
-
The synthesis of yolk/shell spheres including a movable magnetic core, a poly(ionic liquid)s-derived porous carbon shell, and nickel nanoparticles confined within the porous shell is reported. The as-prepared carbon shell is graphitic and porous, as proven by X-ray diffraction, Brunauer-Emmett-Teller equation, and transmission electron microscopy characterizations. The ensuing catalyst has been employed for the tandem dehydrogenation of sodium borohydride and hydrogenation of several nitro/nitrile compounds in aqueous media, which resulted in high yields with a very low amount of the catalyst.
- Nabid, Mohammad Reza,Bide, Yasamin,Habibi, Zahra
-
p. 2258 - 2265
(2015/02/02)
-
- Preparation and characterization of primary amines by potassium borohydride-copper chloride system from nitriles
-
Nitriles undergo reduction to primary amines under optimized conditions at 50 °C using 0.25 equiv of copper chloride and 3.0 equiv of potassium borohydride in 80 % isopropanol. The aromatic and aralkyl nitriles could be effectively reduced in yield ranging from 60 to 90 %.
- Jiang, Han,Hu, Jialei,Xu, Xinliang,Zhou, Yifeng
-
p. 3564 - 3566
(2015/12/30)
-
- METHOD FOR PRODUCING N-SUBSTITUTED AMINE COMPOUNDS THROUGH CATALYZED ALKYLATION
-
The invention relates to a method for producing a N-substituted amine compound by catalyzed alkylation. The method uses amine and alcohol or two kinds of amines as the reaction materials, employs composite metal oxides catalyst at a reaction temperature of 80-180° C. to catalyze the reaction for 6-36 hours, so as to produce the N-substituted amine compound. The reaction condition of the method of the invention is relatively moderate, using a catalyst made of cheap non-noble metals, which is non-caustic and easy to be separated and reused. The reaction does not need any medium and has relatively high conversion rate and selectivity.
- -
-
Paragraph 0045
(2014/02/16)
-
- Selective catalytic transfer hydrogenation of nitriles to primary amines using Pd/C
-
The catalytic transfer hydrogenation of (hetero)aryl nitriles using ammonium formate has been investigated in detail. In the presence of commercially available Pd/C, a straightforward and selective reduction is achieved without any additives under mild conditions.
- Vilches-Herrera, Marcelo,Werkmeister, Svenja,Junge, Kathrin,Boerner, Armin,Beller, Matthias
-
p. 629 - 632
(2014/03/21)
-
- Asymmetric hydrogenation of tert-alkyl ketones: DMSO effect in unification of stereoisomeric ruthenium complexes
-
Face off: The ruthenium complexes of a new axially chiral PNNligand (L) are highly efficient in the presence of dimethylsulfoxide (DMSO) for hydrogenation of both functionalized and unfunctionalized tert-alkyl ketones. DMSO is thought to narrow down the many possible complex stereoisomers into a single facial L/Ru complex, thus enhancing the reactivity, selectivity, and productivity. Copyright
- Yamamura, Tomoya,Nakatsuka, Hiroshi,Tanaka, Shinji,Kitamura, Masato
-
supporting information
p. 9313 - 9315
(2013/09/12)
-
- SPIROHYDANTOIN COMPOUNDS AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS
-
The present invention relates to a compound of formula (1-1 ) in free form or in pharmaceutically acceptable salt form in which the substituents are as defined in the specification; to its preparation, to its use as a medicament and to medicaments comprising it. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
- -
-
Page/Page column 76; 77
(2013/09/12)
-
- Ceric ammonium nitrate-mediated detritylation of tritylated amines
-
Efficient deprotection of tritylated amines to the corresponding amines mediated by 20 mol % ceric ammonium nitrate [Ce(NH4) 2(NO3)6, CAN], 10 equiv of acetic acid and 15 equiv of water in dichloromethane is presented. This method equally worked well in the case of morpholino nucleosides.
- Pattanayak, Sankha,Sinha, Surajit
-
experimental part
p. 34 - 37
(2011/02/25)
-
- PROCESS FOR PREPARING AMINES FROM ALCOHOLS AND AMMONIA
-
The present invention provides novel ruthenium based catalysts, and a process for preparing amines, by reacting a primary alcohol and ammonia in the presence of such catalysts, to generate the amine and water. According to the process of the invention, primary alcohols react directly with ammonia to produce primary amines and water in high yields and high turnover numbers. This reaction is catalyzed by novel ruthenium complexes, which are preferably composed of quinolinyl or acridinyl based pincer ligands.
- -
-
Page/Page column 24; 31; 32
(2010/04/03)
-
- Selective synthesis of primary amines directly from alcohols and ammonia
-
(Chemical Equation Presented) Air stable and waterproof: Selective and efficient synthesis of primary amines directly from alcohols and ammonia is achieved under mild conditions (see scheme). The reaction is homogenously catalyzed by a novel air-stable ruthenium pincer complex and can proceed in toluene or even in the absence of solvent or "on water".
- Gunanathan, Chidambaram,Milstein, David
-
supporting information; experimental part
p. 8661 - 8664
(2009/05/15)
-
- Voltammetric, potentiometric and spectrophotometric studies of some hydrazones and their metal complexes in ethanolic-aqueous buffered solutions
-
The electrochemical behavior of some hydrazones derived from 6-chloro-2-hydrazinopyridine in the Britton-Robinson universal buffer of pH 2-11 containing 35% ethanol was investigated at the mercury electrode using dc-polarography, controlled-potential coulometry, and cyclic voltammetry techniques. The examined hydrazones were reduced in solutions of pH 2 single bond. The mechanistic pathway of the electrode reaction of the studied compounds was elucidated and discussed. The pK a values of the examined hydrazones and the stoichiometry of their complexes in solution with some transition metal ions were determined spectrophotometrically. The dissociation constants and the thermodynamic parameters of the investigated hydrazones, and the stability constants of their metal complexes in solution were determined potentiometrically. Springer-Verlag 2006.
- Ghoneim, Mohammed M.,El-Hallag, Ibrahim S.,El-Baradie, Kamal Y.,El-Desoky, Hanaa S.,El-Attar, Mona A.
-
p. 285 - 299
(2007/10/03)
-
- Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
-
Oligomeric compounds comprising a plurality of aminodiol monomer subunits joined by linking groups are provided, as well as libraries of such compounds and processes for preparing the oligomeric compounds and libraries.
- -
-
-
- Fused pyrazole derivatives bieng protein kinase inhibitors
-
Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, (R2, and R4 are various substituent groups, are protein kinase inhibitors.
- -
-
-
- 2-aminopyridine derivatives and combinatorial libraries thereof
-
The present invention relates to novel 2-aminopyridine derivative compounds of the following formula: wherein R1to R5have the meanings provided herein. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing 2-aminopyridine derivative compounds.
- -
-
-
- Benzothiazole derivatives with activity as adenosine receptor ligands
-
The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.
- -
-
-
- Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
-
Derivatives of Phenyl Cycloamino Pyrimidinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
- -
-
-
- PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS
-
Compounds of the formula and pharmaceutically acceptable salts thereof, wherein R 1 is H, C 1 -C 4 alkyl CN or CONR 4 R 5 ; R 2 is C 2 -C 4 alkyl; R 3 is SO 2 NR 6 R 7, NO 2, NH 2, NHCOR 8 NHSO 2 R 8 or N(SO 2 R 8) 2 ; R 4 and R 5 are each independently selected from H and C 1 -C 4 alkyl; R 6 and R 7 are each independently selected from H and C 1 -C 4 alkyl optionally substituted with CO 2 R 9, OH, pyridyl 5-isoxazolin-3-onyl, morpholino or 1-imidazolidin-2-onyl; or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, morpholino, 1-pyrazolyl or 4-(NR 10)-1-piperazinyl group wherein any of said groups may optionally be substituted with one or two substituents selected from C 1 -C 4 alkyl, CO 2 R 9, NH 2 and OH; R 8 is C 1 -C 4 alkyl or pyridyl; R 9 is H or C 1 -C 4 alkyl; and R 10 is H, C 1 -C 4 alkyl or (hydroxy) C 2 -C 3 alkyl; are selected cGMP PDE inhibitors useful in the treatment of, inter alia, cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis
- -
-
-
- Synthesis of primary amines via nucleophilic addition of organometallic reagents to aldimines on solid support
-
Resin-immobilized aldimines 5, derived from the condensation of amine-functionalized Rink polystyrene resin with aldehydes, react with Grignard reagents, lithium reagents or LiBH4 to afford a wide variety of primary amines in good to excellent yields upon trifluoroacetic acid cleavage. In this amine synthesis, Rink resin functions both as a solid support and as a NH protecting group.
- Katritzky, Alan R.,Xie, Linghong,Zhang, Guifen,Griffith, Michael,Watson, Karen,Kiely, John S.
-
p. 7011 - 7014
(2007/10/03)
-
- 1-aminophosphonic acids and esters bearing heterocyclic moiety. Part 2. 1 pyridine, pyrrole and emidazole derivatives
-
The benzylic amines (benzylamine, benzhydrylamine and benzyl carbamate) were applied in the synthesis of aminophosphonates derived from pyridine, pyrrole and imidazole. The Schiff bases obtained from corresponding heterocyclic aldehydes and benzylic amines were caused to react with diphenyl phosphorate or dibenzyl phosphonate to form corresponding heterocyclic aminophosphonates in good yields. The N-(benzylamino)-phosphonates were deblocked by catalytic hydrogenolysis. The benzhydryl group from the phosphonates was removed by acidic hydrolysis, and the carbobenzyloxy group from the phosphonates can be easy removed by treatment with a solution of 30% HBr in acetic acid, as well. It was found that during acidic hydrolysis of 2-and 4-pyridylmethylaminophosphonates a rearrangement occurred, combined with a cleavage of C-P bond in the phosphonate molecules and subsequent formation of the corresponding amines.
- Boduszek, Bogdan
-
p. 209 - 218
(2007/10/03)
-
- The acidic cleavage of pyridylmethyl(amino)phosphonates. Formation of the corresponding amines
-
Hydrolysis of 3-pyridylmethyl(amino)phosphonates by means of 20% aq. hydrochloric acid gave corresponding 3-pyridimethyl(amino)phosphonic acids, as expected. However, hydrolysis of 2- and 4-pyridylmethyl(amino)phosphonates led to decomposition of the phosphonates with a cleavage of C-P bond and formation of the corresponding amines. The leaving phosphorus moiety was identified as phosphoric acid. The scope of the reaction is limited to 2- and 4-pyridylmethyl derivatives of aminophosphonic acids and their esters, as well as to the derivatives possessing similar structure. On the contrary, the basic hydrolysis of 2- and 4-pyridylmethyl(amino)phosphonates led to the corresponding monoalkyl esters of the aminophosphonates, and no cleavage of C-P bond was observed in those cases.
- Boduszek, Bogdan
-
p. 12483 - 12494
(2007/10/03)
-
- PHENYLALKYL OXAMIDES
-
Novel oxamide derivatives are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful as inhibitors of PDE IV and are therefor useful in the treatment of disease states mediated or exacerbated thereby
- -
-
-
- Electrolytic reduction of pyridine-2-carboxaldehyde-2-quinolylhydrazone at pyrolytic graphite electrode
-
The electrochemical reduction of pyridine-2-carboxaldehyde-2-quinolylhydrazone at pyrolytic graphite electrode has been studied in the phosphate buffers of pH range 3.0-10.8.The products of reduction have been characterized.On the basis of linear and cyclic sweep voltammetry, coulometry, spectral studies and product identification, a redox mechanism has been suggested.
- Mathur, Navin C.,Goyal, R. N.,Malik, W. U.
-
p. 765 - 769
(2007/10/02)
-
- INTRAMOLECULAR GENERAL-BASE CATALYSIS OF SCHIFF-BASED HYDROLYSIS BY TERTIARY AMINO GROUPS.
-
Hydrolysis of a series of Schiff bases derived from benzophenone and various amines has been studied kineticlly in aqueous solution. A linear correlation of the log of the rate constants for the water reaction with the Schiff base pK//a (slope minus 0. 70) shows large positive deviations for Schiff bases derived from (2-aminoethyl)diethylamine, N-(2-aminoethyl)morpholine, N-(2-aminoethyl)piperazine and 2-(aminomethyl)pyridine (1i) but small deviations for Schiff bases from N-(3-aminopropyl)morpholine and 2-(2-aminoethyl)pyridine. The deviations found are attributed to intramolecular general-base catalysis of the water reaction by the internal tertiary amino groups. Magnitudes of the rate enhancement are correlated well with pK//a//l of the internal catalyst ( beta equals 0. 49). Effective concentrations of the internal bases are estimated to range from 340 (1e) to 40 M.
- Okuyama,Shibuya,Fueno
-
p. 730 - 736
(2007/10/02)
-
- Studies on 1,3-Benzoxazines. II. New Rearrangement Modes in the Reaction of 4-Chloro-2,2-dimethyl-2H-1,3-benzoxazine with Substituted Pyridine N-Oxides
-
New rearrangement modes in the reaction of 4-chloro-2,2-dimethyl-2H-1,3-benzoxazine (1) with various α- and/or γ-substituted pyridine N-oxides are described.The benzoxazine moiety was introduced into the side chain and/or β-position of the pyridine ring, in addition to the α-position.Possible mechanism of the reactions are discussed.Keywords - 1,3-benzoxazine; picoline N-oxide; lutidine N-oxide; imidoyl chloride; rearrangement.
- Wachi, Kazuyuki,Terada, Atsusuke
-
p. 3020 - 3028
(2007/10/02)
-
- Preparation of esters of phosphorus acids
-
Esters of phosphorus acids are prepared by an improved process whereby aromatic alcohols and phosphorus halides are reacted at specified temperatures in the presence of amine catalysts thereby providing high yields of substantially pure esters and allowing preparation of selected halogen-containing mono- and di-esters of phosphorus acids wherein halogen is directly bonded to phosphorus having substantially no side reactant contamination. The phosphorus esters are useful as intermediates in the preparation of plasticizers, oil additives and functional fluids.
- -
-
-
- 9-Xanthylamin oalkylpyridine derivatives
-
9-Xanthylaminoalkylpyridine derivatives are prepared. These compounds are inhibitors of gastric acid secretion.
- -
-
-