The invention discloses a synthetic method of trimethoprim. Trimethoprim is synthesized from 3,4,5-trimethoxybenzaldehyde and ethyl cyanoacetate. The method has the advantages of high conversion rate, short time, and industrial production facilitation.
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(2016/10/08)
An efficient benzyltriethylammonium chloride catalysed preparation of electrophilic alkenes: a practical synthesis of trimethoprim
The Knoevenagel condensation of carbonyl compounds with active methylene compounds was readily carried out with benzyltriethylammonium chloride as a catalytic agent, under solvent-free conditions to produce olefinic products in high yeilds: the scope of this protocol is utilised for the synthesis of the antibacterial agent trimethoprim.
Bose, D. Subhas,Narsaiah, A. Venkat
p. 36 - 38
(2007/10/03)
Benzylcyano-amides
Benzylcyano-acids and amides useful as intermediates in the preparation of pharmaceutically valuable 2,4-diamino-5-benzyl pyrimidines.
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(2008/06/13)
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