- Reaction of 2-acetyl-5-methyl-2H-1,2,3-diazaphosphole with butane-2,3-diol
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The reaction of 2-acetyl-5-methyl-2H-1,2,3-diazaphosphole with (rac)-butane-2,3-diol at temperatures below 0 °C leads to the formation of a hydrospirophosphorane containing both a diazaphospholene and a dioxaphospholane ring system and a β-hydroxy-alkoxy-1,2,3-diazaphospholene. On heating, these products form a hydrospirotetraoxaphosphorane, its tautomeric monocyclic β-hydroxyalkylphosphite and N-acetyl-N'-isopropylidene-hydrazine.
- Khusainova, Narkis G.,Mostovaya, Olga A.,Azancheev, Nail M.,Litvinov, Igor A.,Krivolapov, Dmitry B.,Cherkasov, Rafael A.
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Read Online
- BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE
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Benzoxazepin Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
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Page/Page column 125
(2012/10/08)
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- Catalytic hydrophosphorylation of alkyl- and acylhydrazones
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N-Boc- and N-acylhydrazino phosphonates were obtained for the first time by hydrophos- phorylation of the appropriate hydrazones of aliphatic and aromatic aldehydes and heterocyclic and aliphatic ketones in the presence of [tetra(tert-butyl)phthalocyanine
- Matveeva,Podrugina,Kolesnikova,Prisyazhnoi,Karateev,Zefirov
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experimental part
p. 418 - 424
(2011/02/17)
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- 1-Acyl-2-alkylhydrazines by the Reduction of Acylhydrazones
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1-Acyl-2-alkylhydrazines were easily prepared by the reduction of acylhydrazones with triethylsilane in the presence of trifluoroacetic acid.
- Pei-Lin-Wu,Peng, Shao-Yu,Magrath, Joe
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p. 435 - 438
(2007/10/02)
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- THE REACTIONS OF 1,2,3-DIAZAPHOSPHOLE DERIVATIVES WITH CATECHOL
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Both two-coordinated phosphorus compounds (1) and tri-coordinated phosphorus compounds (2) reacted with catechol in the presence of triethylamine to yield hexa-coordinated phosphorus compound R3P-H+N(Et)3 (3, R = -O-C6H4-O-). 3 were confirmed by elemental analysis, IR, 31P NMR and MS.The mechanism of these reactions was suggested.
- Chen, Ruyu,Cai, Baozhong
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- Reaction of carbonyl ylides with chloroform
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Carbonyl ylides 2, generated by thermolysis of alkoxyoxadiazolines 1 in chloroform, react with chloroform to form ketals (3) of 1,1,1-trichloropropanone.The isotope effect at 80 deg C, determined by analysis of products from thermolysis of 1 in mixed solvent (CHCl3/CDCl3, both in large excess) was estimated to be kH/kD = 5.A mechanism involving concerted C-Cl and C-H bond formation between the ylide C atoms and the Cl and H atoms of chloroform is proposed.The ketals of 1,1,1-trichloropropanone are the first to be reported. Key words: carbonyl ylide, reaction with chloroform; chloroform, reaction with carbonyl ylides; ketals, of 1,1,1-trichloropropanone; 1,1,1-trichloropropanone, ketals of
- Bekhazi, Michel,Lawrynowicz, Witold,Warkentin, John
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p. 1507 - 1510
(2007/10/02)
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- Photolysis of 2-Alkoxy-Δ3-1,3,4-oxadiazolines. A New Route to Diazoalkanes
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2-Alkoxy-2,5,5-trialkyl-Δ3-1,3,4-oxadiazolines (2), when photolyzed in solution with 300-nm light, afford the appropriate diazoalkane (3) and ester (4) in high yield.The diazoalkanes undergo intermolecular reaction, giving rise to azines (5), or they can be trapped in situ with 1,3-dipolarophiles to afford cycloadducts (7 or 11), which can in turn be photolyzed to the corresponding cyclopropenes (8) and cyclopropanes (12), respectively.
- Majchrzak, Michael W.,Bekhazi, Michel,Tse-Sheepy, Irene,Warkentin, John
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p. 1842 - 1845
(2007/10/02)
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- CONFORMATIONAL BEHAVIOUR AND E/Z ISOMERIZATION OF N-ACYL AND N-AROYLHYDRAZONES
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The stereochemical behaviour of N-acyl and N-aroylhydrazones of aromatic aldehydes, of pyruvates and of acetone, in polar and less polar solvents, has been studied by HPLC and by NMR techniques.Z/E Geometrical isomers and cis/trans amide conformers have been found for N-acylhydrazones, while for N-aroylhydrazones only geometrical isomers were detected.Energy barriers of isomers are reported, and solvent effects are discussed with regard to hydrogen bond interactions.
- Palla, Gerardo,Predieri, Giovanni,Domiano, Paolo,Vignali, Carlo,Turner, Walter
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p. 3649 - 3654
(2007/10/02)
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