- Short and practical synthesis of N′,N′-disubstituted N-aryl-1,2-ethylene-diamines by a decarboxylative ring-opening reaction under nucleophilic conditions
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A straightforward and practical synthesis of N′,N′- disubstituted N-aryl-1,2-ethylenediamines, starting from anilines, via N-aryloxazolidin-2-ones is described. A decarboxylative ring-opening reaction of N-aryloxazolidin-2-ones, using aliphatic secondary
- Morita, Yasuhiro,Ishigaki, Takeshi,Kawamura, Kuniaki,Iseki, Katsuhiko
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p. 2517 - 2523
(2008/02/13)
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- ANOMALOUS RING OPENING OF N-ARYL-2-OXAZOLIDINONES BY ANHYDROUS ALKOXIDE:A CONVENIENT PREPARATION OF N-(ALKOXYETHYL)-2,6-DISUBSTITUTED ANILINES
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N-(2-Alkoxyethyl)anilines may be prepared by acylation of an N-unsubstituted aniline with 2-chloroethyl chloroformate, ring closure to oxazolidinone, ring opening with alkoxide under anhydrous conditions to a carbamic acid salt, and decarboxylation.This unexpected mode of ring opening is especially useful in the preparation of N-(2-alkoxyethyl)-2,6-disubstituted anilines.
- Fancher, L.W.,Gless, R.D.,Wong, R.Y.
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p. 5095 - 5098
(2007/10/02)
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- Investigation of aryl oxazolidinones and aryl thiazolidinethiones by NMR spectroscopy
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The 1H and 13C resonances of 3-aryl-2-oxazolidinones and 3-aryl-2-thiazolidinethiones have been examined.The conformational isomers of restricted rotation about the aryl C-N bond could not be detected for both of the nuclei.The additive shift parameters, measured for carbon chemical shifts, are found to be higher in the sulphur substituted hetero ring.
- Aksac, Z.,Altinok, A.,Icli, S.
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p. 1029 - 1032
(2007/10/02)
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