- PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME
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Phenylpyridazine compounds represented by the following formula (I): (wherein R1 represents a substituted or unsubstituted phenyl or a a substituted or unsubstituted pyridyl; R2 represents a lower alkoxy group, a lower alkylthio group, a lower alkylsufiny
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- Phenylpyridazine compounds and medicines containing the same
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Phenylpyridazine compounds represented by the following formula (I): are provided, wherein R1, R2, R3, R4, and n are as defined herein having excellent inhibitory activity against interleukin-1β production, and
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Page column 32
(2010/02/05)
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- Synthesis and bioactivities of novel pyridazine derivatives: Inhibitors of interleukin-1 beta (IL-1β) production
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New pyridazine derivatives were prepared, and their abilities to inhibit IL-1β production were evaluated. Some compounds showed potent inhibitory activity against IL-1β production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure-activity relationships of these compounds are described.
- Matsuda, Takayuki,Aoki, Taro,Ohgiya, Tadaaki,Koshi, Tomoyuki,Ohkuchi, Masao,Shigyo, Hiromichi
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p. 2369 - 2372
(2007/10/03)
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