The present invention relates to a protein encapsulated by an encapsulating organic compound (EOC) or proteophore wherein the protein and the encapsulating organic compound are present in 1:1 stoichiometry. In one embodiment of the present invention, the
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Polymeric prodrugs
A molecule is disclosed having the following structure: wherein T is D or A D being a residue of an amine containing biologically active molecule and A being a leaving group.
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S-4-Methoxytrityl mercapto acids: Synthesis and application
4-Methoxytrityl (Mmt)-mercapto acids were obtained either by the reaction of mercapto acids with Mmt-chloride or by the reaction of halo acids with Mmt-thiol. The derivatives obtained were used in the solid-phase synthesis of small libraries of mercaptoacylamino acids and mercaptoacyl peptides. The removal of the Mmt-group was performed by treatment with trifluoroacetic acid (TFA) in dichloromethane (DCM) using triethylsilane (TES) as scavenger.