- Extractant as well as preparation method and application thereof
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The invention relates to the field of separation and enrichment of metals, in particular to an extractant, a preparation method and application thereof. The preparation method comprises the followingsteps that a phenol compound reacts with a halogenated carboxylic acid derivative or halogenated carboxylate in a solvent, then acidifying is carried out, and the phenoxy carboxylic acid extractant issynthesized. The prepared extractant can be used for enriching rare earth in rare earth mineral leachate after being saponified by an alkaline compound; compared with the existing extractant, the extractant has the advantages of being higher in precipitation capacity, high in precipitation efficiency and large in precipitation particles, facilitating the separation of a rare earth extraction complex and a water phase and improving the production efficiency; and moreover, the extractant can further be used for selectively recovering/separating valuable metals from different industries.
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Paragraph 0081-0084
(2021/09/15)
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- In silico and pharmacological screenings identify novel serine racemase inhibitors
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d-Serine is a coagonist of the N-methyl-d-aspartate (NMDA)-type glutamate receptor and its biosynthesis is catalyzed by serine racemase (SR). The overactivation of the NMDA receptor has been implicated in the development of neurodegenerative diseases, strokes, and epileptic seizures, thus, the inhibitors of SR have potential against these pathological states. Here, we have developed novel inhibitors of SR by in silico screening and in vitro enzyme assay. The newly developed inhibitors have lower IC50 value comparing with that of malonate, one of the standard SR inhibitor. The structural features of novel inhibitors suggest the importance of central amide structure having a phenoxy substituent in their structure for the SR inhibitory activity. The present findings suggest the importance and rational development of new drugs for diseases of NMDAR overactivation.
- Mori, Hisashi,Wada, Ryogo,Li, Jie,Ishimoto, Tetsuya,Mizuguchi, Mineyuki,Obita, Takayuki,Gouda, Hiroaki,Hirono, Shuichi,Toyooka, Naoki
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p. 3732 - 3735
(2014/09/03)
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- Copper(II)-catalyzed hydroxylation of aryl halides using glycolic acid as a ligand
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Copper(II)-catalyzed hydroxylation of aryl halides has been developed to afford functionalized phenols. The protocol utilizes the reagent combination of Cu(OH)2, glycolic acid, and NaOH in aqueous DMSO, all of which are cheap, readily available, and easily removable after the reaction. A broad range of aryl iodides and activated aryl bromides were transformed into the corresponding phenols in excellent yields. Moreover, it has been shown that C-O(alkyl)-coupled product, instead of phenol, can be predominantly formed under similar reaction conditions.
- Xiao, Yan,Xu, Yongnan,Cheon, Hwan-Sung,Chae, Junghyun
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p. 5804 - 5809
(2013/07/25)
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- COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE
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The present invention provides compounds possessing inhibitory activity against β-adrenergic receptors and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for regulating calcium homeostasis, for treating a disease, disorder or condition in which disregulation of calcium homeostasis is implicated, and for treating hypertension, cardiovascular disease, congestive heart failure, myocardial ischemia, cardiomyopathies, stroke or epilepsy.
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- The Synthesis and Transition Temperatures of Novel Low Molar Mass Cholesteric Materials Derived from (R)-2-(4-Hydroxyphenoxy)propanoic Acid
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A comprehensive series of (R)-2-(4-substituted-phenoxy)propanoates and (R)-2-(4-substituted-phenoxy)propanonitriles have been prepared.A wide variety of 4-substituents and ester functions have been examined to determine how the position of the chiral centre affects the cholesteric phase formation in these classes of materials; the synthesis of these novel materials, their transition temperatures and a procedure for assessing their optical purity are described and discussed.Mesogenicity is significantly depressed if the chiral centre is placed centrally within the molecule.
- Booth, Christopher J.,Gray, George W.,Toyne, Kenneth J.,Hardy, Judith
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