cas 38993-84-9, (1-Methyl-1H-imidazol-5-yl)methanol | Articles data ｜lookchem

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38993-84-9

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Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof
The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.
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(2008/06/13)

An Effective Chirospecific Synthesis of (+)-Pilocarpine from L-Aspartic Acid
A short and efficient synthesis of (+)-pilocarpine (1) has been accomplished in 10 steps and 51percent overall yield from L-aspartic acid.The synthesis features a diastereoselective alkylation of a protected aspartic acid diester derivative and a selective hydrolysis of the α-methyl ester to give the corresponding amino acid.Subsequent replacement of the amino group with bromo, esterification, and a modified Reformatsky reaction with 1-methylimidazole-5-carboxaldehyde (8) afforded imidazole-substituted lactone 28.Details concerning this novel lactone synthesis are also described.Finally, hydrogenolysis of the lactone carbon-oxygen bond and selective reduction of the resulting monoester afforded pure (+)-pilocarpine (1).
Dener, Jeffrey M.,Zhang, Lin-Hua,Rapoport, Henry
p. 1159 - 1166
(2007/10/02)

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Chemical Properties

Melting Point: 113 °C
Boiling Point: 324.872 °C at 760 mmHg
Flash Point:150.278 °C
Density: 1.167 g/cm³
Solubility:DMSO (Sparingly), Methanol (Slightly)
Storage Temp.:Inert atmosphere,Room Temperature
Vapor Pressure: 9.76E-05mmHg at 25°C
Refractive Index: 1.552
PKA: 14.35±0.10(Predicted)
PSA: 38.05000
LogP: -0.08760

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