- Selective monomethyl esterification of linear dicarboxylic acids with bifunctional alumina catalysts
-
An environmentally friendly protocol for the selective protection of dicarboxylic acids is reported using methanol as a cheap esterifying agent and alumina as a heterogeneous catalyst; the selectivity of the process has been ascribed to a balanced acidity/basicity of the bifunctional alumina catalyst.
- Santacroce, Veronica,Bigi, Franca,Casnati, Alessandra,Maggi, Raimondo,Storaro, Loretta,Moretti, Elisa,Vaccaro, Luigi,Maestri, Giovanni
-
supporting information
p. 5764 - 5768
(2016/11/06)
-
- Antitrypanosomal acetylene fatty acid derivatives from the seeds of Porcelia macrocarpa (Annonaceae)
-
Chagas' disease is caused by a parasitic protozoan and affects the poorest population in the world, causing high mortality and morbidity. As a result of the toxicity and long duration of current treatments, the discovery of novel and more efficacious drugs is crucial. In this work, the hexane extract from seeds of Porcelia macrocarpa R.E. Fries (Annonaceae) displayed in vitro antitrypanosomal activity against trypomastigote forms of T. cruzi by the colorimetric MTT assay (IC50 of 65.44 μg/mL). Using chromatographic fractionation over SiO2, this extract afforded a fraction composed by one active compound (IC50 of 10.70 μg/mL), which was chemically characterized as 12,14-octadecadiynoic acid (macrocarpic acid). Additionally, two new inactive acetylene compounds (α,α′-dimacro-carpoyl-β-oleylglycerol and α-macrocarpoyl-α′-oleylglycerol) were also isolated from the hexane extract. The complete characterization of the isolated compounds was performed by analysis of NMR and MS data as well as preparation of derivatives.
- Santos, Luciana de á.,Cavalheiro, Alberto J.,Tempone, Andre G.,Correa, Daniela S.,Alexandre, Tatiana R.,Quintiliano, Natalia F.,Rodrigues-Oliveira, AndréF,Oliveira-Silva, Diogo,Martins, Roberto Carlos C.,Lago, Jo?o Henrique G.
-
p. 8168 - 8180
(2015/05/20)
-
- Direct terminal alkylamino-functionalization via multistep biocatalysis in one recombinant whole-cell catalyst
-
Direct and regiospecific amino-functionalization of non-activated carbon could be achieved using one recombinant microbial catalyst. The presented proof of concept shows that heterologous pathway engineering allowed the construction of a whole-cell biocatalyst catalyzing the terminal amino-functionalization of fatty acid methyl esters (e.g., dodecanoic acid methyl ester) and alkanes (e.g., octane). By coupling oxygenase and transaminase catalysis in vivo, both substrates are converted with absolute regiospecificity to the terminal amine via two sequential oxidation reactions followed by an amination step. Such demanding chemical three-step reactions achieved with a single catalyst demonstrate the tremendous potential of whole-cell biocatalysts for the production of industrially relevant building blocks. Copyright
- Schrewe, Manfred,Ladkau, Nadine,Buehler, Bruno,Schmid, Andreas
-
supporting information
p. 1693 - 1697
(2013/07/19)
-
- PROCESS FOR PRODUCING DODECANE-1, 12-DIOL BY REDUCTION OF LAURYL LACTONE PRODUCED FROM THE OXIDATION OF CYCLODODECANONE
-
A process for synthesizing dodecane-1,12-diol, and by-products thereof, by the reduction of lauryl lactone produced from the oxidation of cyclododecanone.
- -
-
Paragraph 00131
(2013/08/15)
-
- Methylation of Alcohols, Phenols, and Carboxylic Acids, and Selective Monomethylation of Diols and Dicarboxylic Acids with Dimethyl Sulfate by Use of Alumina
-
Alcohols in cyclohexane give their methyl ethers in high yields by the use of a combination of dimethyl sulfate and alumina.Some diols and dicarboxylic acids adsorbed on alumina react with dimethyl sulfate and produce the corresponding monomethyl ethers and esters in high selectivities.
- Ogawa, Haruo,Ichimura, Youko,Chihara, Teiji,Teratani, Shousuke,Taya, Kazuo
-
p. 2481 - 2484
(2007/10/02)
-
