- Synthesis of coumarin/pyrrole-fused heterocycles and their photochemical and redox-switching properties
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Two coumarin/pyrrole-fused heterocycles were synthesized to investigate their photochemical and redox-switching properties. Photooxidation of the colorless diphenyl-substituted pyrrolocoumarin resulted in a distinct change to red and a sharp decrease in f
- Lin, Chi-Hui,Yang, Ding-Yah
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supporting information
p. 2802 - 2805
(2013/07/26)
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- Anti-tumor compounds
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The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of the formula: STR1 wherein R1 includes hydrogen, amino and alkyl or alkoxy each of up to 4 carbon atoms; R2 includes hydrogen, alkyl, hydroxyalkyl and halogenoalkyl each of up to 4 carbon atoms; R3 is hydrogen or alkyl or up to 3 carbon atoms; Ar is phenylene or heterocyclene; L is a group of the formula --CO.NH--, --NH.CO--, --CO.NR4 --, --NR4.CO--, --CH=CH-- or --CO.O--, wherein R4 is alkyl of up to 4 carbon atoms; and Y is a branched alkyl group bearing substituents Y2 and Y3 the definition of each independently including hydroxy, cyano, aryl and heteroaryl, and the definition of Y3 also optionally including sulpho, N-phenylsulphonylcarbamoyl and 5-tetrazolyl; or a pharmaceutically-acceptable salt thereof.
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- ISOQUINOLINE SYNTHESIS VIA 2-OXAZOLINES. PART VI. TRANSFORMATION OF 1-BENZAMIDO-1-PHENYL-2-ALKANOLS INTO 4-ALKYL-1-PHENYLISOQUINOLINES
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Conditions necessary for the transformation of 1-benzamido-1-phenyl-2-alkanols (1) and 5-alkyl-2,4-diphenyl-2-oxazolines (2) into 4-alkyl-1-phenylisoquinolines (3) have been determined.The mechanism proposed for these reactions is supported by the results
- Kopczynski, Tomasz,Krzyzanowska, Ewa
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p. 471 - 482
(2007/10/02)
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