- Preparation of 5,6-diaryl-2,2-bipyridines using a 1,2,4-triazine methodology
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New unsymmetric 5,6-diaryl-2,2-bipyridines were synthesized in high yields using a 1,2,4-triazine methodology. Their photophysical properties were studied.
- Kopchuk,Chepchugov,Kim,Zyryanov,Kovalev,Rusinov,Chupakhin
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- Columnar Iridium(III) Metallomesogens Based on Polycatenar Pyridyltetrazolate with Ambipolar Carrier Mobility Behavior
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In this paper, we have designed and synthesized a series of neutral liquid-crystalline iridium(III) complexes based on polycatenar 2,5-diphenylpyridine and pyridyltetrazolate derivatives. Iridium(III) complexes all display highly emissive behavior with photoluminescence quantum yields in the range of 0.45-0.66 and a maximum emission wavelength at ～563 nm. Hexagonal columnar mesophases of iridium(III) complexes can be obtained by changing the number and length of peripheral alkoxyl chains attached to a 2,5-diphenylpyridine ligand (main ligand) and a pyridyltetrazolate ligand (auxiliary ligand). Moreover, experimental results of the charge transport properties for these iridium(III) complexes, which were measured by the space charge limited-current method, exhibit ambipolar carrier mobility behavior. In particular, the liquid-crystalline iridium(III) complexes can self-organize into one-dimensional (1D) nanostructure after thermal annealing treatment in their liquid-crystalline phase. The devices based on liquid crystal film display improved charge transport behavior compared with that of the devices based on polycrystalline film, indicating 1D nanostructure is beneficial to charge carrier injection and transportation.
- Zou, Guo,Zhao, Li,Zeng, Longwei,Luo, Kaijun,Ni, Hailiang,Wang, Haifeng,Li, Quan,Yu, Wenhao,Li, Xuelian
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supporting information
p. 861 - 869
(2019/01/11)
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- Have ambipolar carrier transmission property based on novel platinum(II) complexes: Synthesis, photophysical properties, liquid crystalline characteristics, polarized luminescence
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A series of new platinum (II) complexes were obtained, where 2-phenylpyridine derivatives are used as the main ligand and 5-substitued tetrazole are used as the auxiliary ligand. Although the complexes with one or without any peripheral flexible around rigid core do not reveal liquid crystallinity, the complexes with three flexible alkoxy chains attached to 2-phenylpyridine and tetrazole display liquid crystalline property. In order to investigate the self-assembly behavior of the liquid crystalline complexes, their polarized luminescence is researched, and the maximum polarization ratio can reach 7.1 at room temperature. Moreover, the ambipolar carrier mobility was measured in these neutral cyclometalated platinum (II) complexes, the electron mobility and hole mobility can reach 3.3 × 10?4 cm2/(V·S) and 6.3 × 10?5 cm2/(V·S), respectively.
- Geng, Hao,Luo, Kaijun,Zou, Guo,Zhao, Li,Wang, Haifeng,Li, Quan,Ni, Hailiang
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- Transition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions
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A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.
- Zhang, Xitao,Feng, Xiujuan,Zhou, Chuancheng,Yu, Xiaoqiang,Yamamoto, Yoshinori,Bao, Ming
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supporting information
p. 7095 - 7099
(2018/11/23)
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- C?H Cyanation of 6-Ring N-Containing Heteroaromatics
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Heteroaromatic nitriles are important compounds in drug discovery, both for their prevalence in the clinic and due to the diverse range of transformations they can undergo. As such, efficient and reliable methods to access them have the potential for far-reaching impact across synthetic chemistry and the biomedical sciences. Herein, we report an approach to heteroaromatic C?H cyanation through triflic anhydride activation, nucleophilic addition of cyanide, followed by elimination of trifluoromethanesulfinate to regenerate the cyanated heteroaromatic ring. This one-pot protocol is simple to perform, is applicable to a broad range of decorated 6-ring N-containing heterocycles, and has been shown to be suitable for late-stage functionalization of complex drug-like architectures.
- Elbert, Bryony L.,Farley, Alistair J. M.,Gorman, Timothy W.,Johnson, Tarn C.,Genicot, Christophe,Lallemand, Bénédicte,Pasau, Patrick,Flasz, Jakub,Castro, José L.,MacCoss, Malcolm,Paton, Robert S.,Schofield, Christopher J.,Smith, Martin D.,Willis, Michael C.,Dixon, Darren J.
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supporting information
p. 14733 - 14737
(2017/10/07)
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- A Bifunctional Reagent Designed for the Mild, Nucleophilic Functionalization of Pyridines
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Herein is reported the design and application of a reagent for the direct functionalization of pyridines. These reactions occur under mild conditions and exhibit broad functional group tolerance, enabling the late-stage functionalization of drug-like molecules. The reagent can be easily prepared on large scale from inexpensive reagents, and reacts in the title reaction with acetonitrile, sodium chloride, and sodium methanesulfonate as the sole byproducts. Although this Communication focuses primarily on reactions with cyanide as nucleophile, preliminary experiments with other nucleophiles foreshadow the broad reaching synthetic utility of this approach.
- Fier, Patrick S.
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supporting information
p. 9499 - 9502
(2017/07/24)
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- Compositions and methods for modulating a kinase cascade
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The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
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Page/Page column 152
(2009/06/27)
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- Compounds and compositions as anticoagulants
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The present invention relates to novel biheterocyclic derivatives which are factor Xa inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.
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- Site-Selectivity in the Cyanation of 3-Substituted Pyridine 1-Oxides with Trimethylsilanecarbonitrile
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The cyanation of 3-halo-, 3-methoxy-, and 3-dimethylaminopyridine 1-oxide with trimethylsilanecarbonitrile gave predominantly the corresponding 3-substituted 2-pyridinecarbonitriles.The deoxygenation of nitropyridine 1-oxides to nitropyridines with the same reagent is also described.Keywords - site-selective reaction; trimethylsilanecarbonitrile; pyridine 1-oxide; 2-pyridine-carbonitrile; nitropyridine 1-oxide; deoxygenation; aromatic amine N-oxide; cyanation
- Sakamoto, Takao,Kaneda, Soh-ichi,Nishimura, Sumiko,Yamanaka, Hiroshi
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p. 565 - 571
(2007/10/02)
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- SYNTHESIS AND STRUCTURE OF MESOMORPHIC 2-CYANO-5--PYRIDINES
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Liquid-crystal 2-cyano-5-pyridines were synthesized by the reaction of 1-dimethylamino-3-dimethylimmonia-2-propene perchlorates with 2-acetylfuran and subsequently through 2-furyl-5-pyrylium perchlorates and 2-(2-furyl)-5-pyridines by conversion of the latter to 5-alkyl(alkoxy)phenylpyridine-2-carboxylic acids, from which the cyano derivatives were obtained by the usual scheme through the amides.The intermediate arylfurylpyridines and arylpyridine-2-carboxylic acid imides also display liquid-crystal properties.
- Pavlyuchenko, A. I.,Titov, V. V.,Smirnova, N. I.,Grachev, V. T.
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p. 681 - 684
(2007/10/02)
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