- Antiprotozoal activity and DNA binding of dicationic acridones
-
Dicationic acridone derivatives were synthesized and their antiparasitic activity was evaluated. Acridones displayed in vitro nanomolar IC50 values against Trypanosoma brucei rhodesiense STIB900 with selectivity indices >1000. Compounds 1b, 3a,
- Montalvo-Quirós, Sandra,Taladriz-Sender, Andrea,Kaiser, Marcel,Dardonville, Christophe
-
-
Read Online
- Therapeutic acridone and acridine compounds
-
The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is absent, alpha is
- -
-
Page/Page column 46; sheet 3
(2008/06/13)
-