- 8-hydroxy-7-substituted quinolines as anti-viral agents
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The present invention provides for 8-hydroxy-7-substituted quinoline compounds such as formula III These compounds are useful as anti-viral agents. Specifically, these compounds have anti-viral activity against the herpes virus, cytomegalovirus (CMV). Many of these compounds are also active against other herpes viruses, such as the varicella zoster virus, the Epstein-Barr virus, the herpes simplex virus and the human herpes virus type 8 (HHV-8).
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- A facile synthesis of substituted phenylglycines
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A convenient scaleable process for the preparation of substituted phenylglycines 2 by a modified Strecker reaction is described. Bisulfite- mediated addition of benzylamine and cyanide anion to substituted benzaldehydes 3 gave the aminonitriles 4 which were hydrolysed in two steps to the N-protected amino acid 1. Debenzylation using catalytic transfer hydrogenation gave the title compounds in good yield.
- Davies, Antony J.,Ashwood, Michael S.,Cottrell, Ian F.
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p. 1095 - 1102
(2007/10/03)
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- Orally Active Cephalosporins and Penicillins
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A number of orally active cephalosporins and penicillins with interesting biological activity were synthesized.Two of these, 7-glycyl>amino>deacetoxycephalosporanic acid and 7-amino>deacetoxycephalosporanic acid were considerably more active than cephalexin both in vitro and in vivo against staphylococcal and streptococcal infections.
- Boehme, E. H. W.,Bambury, R. E.,Baumann, R. J.,Erickson, R. C.,Harrison, B. L.,et al.
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p. 405 - 412
(2007/10/02)
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