- ANTI-INFECTIVE COMPOUNDS
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The present invention relates to small molecule compounds having the general formula (I): wherein A is a moiety selected from the group consisting of formulae (A) to (K) and their use in the treatment of bacterial infections, in particular Tuberculosis.
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Page/Page column 49
(2016/06/28)
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- NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts
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A NBS-mediated sequential one-pot synthesis of multifunctionalized thiazoles and thiophenes from 1,3-dicarbonyl compounds and mercaptonitrile salts has been developed under mild conditions. This transformation involves sequential bromination/SN
- Luo, Laichun,Meng, Lanlan,Sun, Qi,Ge, Zemei,Li, Runtao
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p. 259 - 263
(2014/01/06)
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- 4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K+-ATPase and Ras oncogene activity in cancer cells
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The in vitro growth inhibitory activity of 26 thiazoles (including 4-halogeno-2,5-disubtituted-1,3-thiazoles) and 5 thienothiazoles was assessed on a panel of 6 human cancer cell lines, including glioma cell lines. (4-Chloro-2-(piperidin-1-yl)thiazol-5-yl)(phenyl)methanone (12a) and (4-bromo-2-(piperidin-1-yl)thiazol-5-yl)(phenyl)methanone (12b) displayed ~10 times greater in vitro growth inhibitory activity than perillyl alcohol (POH), which therapeutically benefits glioma patients through the inhibition of both alpha-1 Na+/K+-ATPase (NAK) and Ras oncogene activity. The in vitro cytostatic activities (as revealed by quantitative videomicroscopy) displayed by 12a and 12b were independent of the intrinsic resistance to pro-apoptotic stimuli associated with cancer cells. Compounds 12a and 12b displayed relatively similar inhibitory activities on purified guinea pig brain preparations that mainly express NAK alpha-2 and alpha-3 subunits, whereas only compound 12b was efficacious against purified guinea pig kidney preparations that mainly express the NAK alpha-1 subunit, which is also expressed in gliomas, melanomas and non-small-cell lung cancers NSCLCs.
- Lefranc, Florence,Xu, Zhanjie,Burth, Patricia,Mathieu, Véronique,Revelant, Germain,Velho De Castro Faria, Mauro,Noyon, Caroline,Garcia, Diogo Gomes,Dufour, Damien,Bruyère, Céline,Gon?alves-De-Albuquerque, Cassiano Felippe,Van Antwerpen, Pierre,Rogister, Bernard,Hesse, Stéphanie,Kirsch, Gilbert,Kiss, Robert
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p. 213 - 223
(2013/07/25)
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- Heterocondensed thiophenes and thiazoles by Thorpe-Ziegler cyclization
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(Chemical Equation Presented) The syntheses of novel thieno-pyridones, thiazolo-pyridones, thiazolo-pyridines and amino- and diamino-dieno-pyridines were described. Simultaneously, it was demonstrated that in these compounds and in the related 3-aminothio
- Gruner, Margit,Boettcher, Gesine,Gewald, Karl
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p. 1071 - 1076
(2008/12/20)
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- A New Synthesis of Substituted 4-Amino-1,3-thiazoles
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In the 5-position substituted 4-amino-2-alkylthio-1,3-thiazoles are prepared in good yields from N-nitro-amidino-dithiocarbamates 1 and α-halogen-carbonylcompounds or chloracetonitrile. 1 reacts with 1,3-dichlor-acetone under formation of adequate bis(1,3
- Evers, R.
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p. 604 - 608
(2007/10/02)
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