A simple method for the synthesis of 2-amino-1(4′-methoxyphenyl)-propane
Synthesis of 2-amino-1-(4′-methoxyphenyl)-propane (II) starting from p-anisaldehyde (1) in 67% overall yield is described. Key reactions involved Horner-Wadswoth-Emmons olefination of 1 to form the ester 2 and Hoffmann degradation of amide 5 to obtain the amine II.
Mereyala,Koduru
p. 3005 - 3010
(2007/10/03)
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