- A new route to pyranocoumarins and their benzannulated derivatives
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A new protocol based on sequential applications of three atom-economic processes viz. Claisen rearrangement, olefin isomerisation, and ring-closing diene metathesis has been developed to access a range of linear and angularly fused pyranocoumarin derivatives. Incorporation of enyne (in place of diene) metathesis and Diels-Alder reaction in the sequence has allowed the corresponding benzannulated derivatives to be prepared in good yields.
- Chattopadhyay, Shital K.,Mondal, Poulomi,Ghosh, Debalina
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p. 3331 - 3340
(2015/02/18)
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- 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor
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A photochemotherapeutic compound of the formula STR1 wherein (i) n is zero, W is a (C1-16) alkyl, alkenyl, or alkynyl linear or branched chain hydrocarbon, having no more than four O, N, or S atoms in or attached to the chain; or (ii) n is 1, W is CR or CR2, and R, R', and R" are independently H or CH3 ; or (iii) N is 2, W is CR or CR2, and R, R', and R" are independently H or CH3 ; and A, B, C, and D are independently selected from hydrogen, alkyl, aryl, halogen, amino, aminoalkyl, nitro, alkoxy, aryloxy, hydroxy, carboxy, haloalkyl, or haloalkoxy, particularly compounds of the foregoing structure in which W is a charged substiuent and n=0 or 1.
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- DDQ Oxidation of 6- or 8-Allyl-7-hydroxycoumarins. A New Synthesis of Benzodipyrandiones and Furobenzopyranones
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A novel synthesis of 2H,8H-benzodipyran-2,8-diones, 2H,8H-benzodipyran-2,8-diones, 2H-furobenzopyran-2-ones, and 7H-furobenzopyran-7-ones was achieved by developing 2-pyrone and furan ring over coumarin. 6- or 8-Allyl-7-hydroxycoumarins on oxidation with 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) afforded benzodipyrandiones and furobenzopyranones.The structures of the compounds now synthesized were established by analytical, spectral, and comparison with authentic samples prepared by the known procedures.
- Prashant, Avula,Krupadanam, Gazula Levi David,Srimannarayana, Gutely
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p. 1191 - 1193
(2007/10/02)
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- 8-Aminoalkyl-4-alkylpsoralens
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The invention relates to 8-aminoalkyl-4-alkylpsoralens having enhanced photosensitizing activity, especially oral activity, including early onset, increased maximum, and rapid decline, as well as low toxicity, when compared with psoralens of different structure.
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