Barbier-type diastereoselective allylation of α-amino aldehydes with an enantiopure 2-sulfinylallyl building block
An optimized procedure for the diastereoselective allylation under aqueous Barbier conditions of a series of α-amino aldehydes with our new chiral building block (Ss)-3-chloro-2-(p-tolylsulfinyl)-1-propene [(Ss)-1a] to afford enantiomerically pure sulfinylamino alcohols in good yields and diastereoselectivites is reported. High levels of diastereoinduction can be achieved from α-amino aldehydes configurationally related to natural α-amino acids.
Marquez, Francesc,Montoro, Raul,Llebaria, Amadeu,Lago, Elena,Molins, Elies,Delgado, Antonio
p. 308 - 311
(2007/10/03)
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