- Conventional and Microwave-assisted Total Synthesis, Antioxidant Capacity, Biological Activity, and Molecular Docking Studies of New Hybrid Compounds
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Thiomorpholine was converted to the corresponding 1,3,4-oxadiazole (4), arylidenehydrazide (5a, 5b, 5c, 5d, 5e), and 1,2,4-triazole (7a and, 7b) derivatives via the formation of hydrazide (3). Compounds 4 and 7 were next converted to the corresponding Man
- Demirci, Serpil,Mermer, Arif,Ak, Gokhan,Aksakal, Fatma,Colak, Nesrin,Demirbas, Ahmet,Ayaz, Faik Ahmet,Demirbas, Neslihan
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Read Online
- Selective Functionalization of Aliphatic Amines via Myoglobin-Catalyzed Carbene N-H Insertion
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Engineered myoglobins have recently gained attention for their ability to catalyze a variety of abiological carbene transfer reactions including the functionalization of amines via carbene insertion into N-H bonds. However, the scope of myoglobin and other hemoprotein-based biocatalysts in the context of this transformation has been largely limited to aniline derivatives as the amine substrates and ethyl diazoacetate as the carbene donor reagent. In this report, we describe the development of an engineered myoglobin-based catalyst that is useful for promoting carbene N-H insertion reactions across a broad range of substituted benzylamines and α-diazo acetates with high efficiency (82-99percent conversion), elevated catalytic turnovers (up to 7,000), and excellent chemoselectivity for the desired single insertion product (up to 99percent). The scope of this transformation could be extended to cyclic aliphatic amines. These studies expand the biocatalytic toolbox available for the selective formation of C-N bonds, which are ubiquitous in many natural and synthetic bioactive compounds.
- Fasan, Rudi,Sreenilayam, Gopeekrishnan,Steck, Viktoria
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supporting information
p. 224 - 229
(2020/02/15)
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- Synthesis of novel Schiff bases and azol-β-lactam derivatives starting from morpholine and thiomorpholine and investigation of their antitubercular, antiurease activity, acethylcolinesterase inhibition effect and antioxidant capacity
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In this study, new Schiff bases and β-lactam derivatives containing morpholine and thio morpholine nuclei were synthesized. Antimicrobial, antioxidant, antimicrobial and antioxidant properties of all synthesized compounds were investigated and highly effe
- Cebeci, Y?ld?z Uygun,Bayrak, Hacer,?irin, Yakup
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- Ruthenium(III) chloride-catalyzed efficient protocol for ethyl diazoacetate insertion into the N-H bond of secondary amines
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Ruthenium(III) chloride (1 mol%) alone can catalyze the insertion of ethyl diazoacetate into N-H bonds of various structurally and electronically diverse secondary cyclic amines under solvent-free conditions to afford the corresponding glycine esters in g
- Varala, Ravi,Enugala, Ramu,Adapa, Srinivas R.
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experimental part
p. 1369 - 1372
(2009/12/04)
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