- Antitumor drugs and methods
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Derivatives of apoptolidin, including skeletal homologues, are potent and selective apoptosis-inducing agents which, unlike apoptolidin, do not undergo isomerization under physiological conditions. These compounds exhibit antitumor properties, often superior to those of apoptolidin, and as such can be used in the treatment of cancer and other hyperproliferative disorders.
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Page/Page column 29-31
(2010/02/07)
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- Total Synthesis of Apoptolidin: Construction of Enantiomerically Pure Fragments
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A general strategy for the total synthesis of the antitumor agent apoptolidin (1) is proposed, and the chemical synthesis of the defined key building blocks (4, 5, 6, 8, and 9) in their enantiomerically pure forms is described. The projected total synthes
- Nicolaou,Fylaktakidou, Konstantina C.,Monenschein, Holger,Li, Yiwei,Weyershausen, Bernd,Mitchell, Helen J.,Wei, Heng-Xu,Guntupalli, Prasuna,Hepworth, David,Sugita, Kazuyuki
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p. 15433 - 15442
(2007/10/03)
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- Total synthesis of apoptolidin: Part 1. Retrosynthetic analysis and construction of building blocks
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No less than 30 stereogenic elements, a highly unsaturated 20-membered macrocyclic system, four carbohydrate units, and unique biological activity, make the natural occurring apoptolidin (1) a challenging synthetic target. The retrosynthetic analysis reve
- Nicolaou,Li, Yiwei,Fylaktakidou, Konstantina C.,Mitchell, Helen J.,Wei, Heng-Xu,Weyershausen, Bernd
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p. 3849 - 3854
(2007/10/03)
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