- Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors
-
The extracellular signal-regulated kinase (ERK) is one of the most important molecular targets for cancer that controls diverse cellular processes such as proliferation, survival, differentiation and motility. Similarly, the Rb (retinoblastoma protein) is
- Kulkarni, Mahesh R.,Mane, Madhav S.,Ghosh, Usha,Sharma, Rajiv,Lad, Nitin P.,Srivastava, Ankita,Kulkarni-Almeida, Asha,Kharkar, Prashant S.,Khedkar, Vijay M.,Pandit, Shivaji S.
-
p. 366 - 378
(2017/04/24)
-
- CYCLOALKYLFUSED INDOLE, BENZOTHIOPHENE, BENZOFURAN AND INDENE DERIVATIVES
-
The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HT1A receptors and mo
- -
-
Page/Page column 49; 25
(2008/06/13)
-
- NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS; PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS THEREOF
-
The present invention relates to novel dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula (I), and their analogs, isomers, pharmaceutical compositions and therapeutic uses, methods of making the same.
- -
-
Page/Page column 28
(2010/02/11)
-
- Rhodium(II) catalyzed intramolecular insertion of carbenoids derived from 2-pyrrolyl and 3-indolyl α-diazo-β-ketoesters and α-diazoketones
-
α-Diazo-β-ketoesters and α-diazoketones derived from 2-pyrrolylacetic, 2-pyrrolylpropionic, 3-indolylacetic and 3-indolylpropionic acids afforded carbenoid derived cyclization products on treatment with catalytic rhodium(II) acetate.
- Cuevas-Ya?ez, Erick,Muchowski, Joseph M.,Cruz-Almanza, Raymundo
-
p. 1505 - 1511
(2007/10/03)
-
- Intramolecular carbenoid insertions: The reactions of α-diazoketones derived from pyrrolyl and indolyl carboxylic acids with rhodium(II) acetate
-
α-Diazoketones derived from pyrrolyl- and indolyl-carboxylic acids were prepared and their Rh2(OAc)4 catalyzed decomposition chemistry was studied. These reactions generally resulted in the alkylation of the heteroaromatic system by the ketocarbenoid and in some instances the systems underwent CH or NH insertions. Evidence that some of these reactions proceed via a cyclopropane intermediate is presented. The methodology described provides facile access to fused pyrrolyl- or indolyl-cycloalkanone systems wherein the carbonyl is beta to the heteroaromatic system. (C) 2000 Elsevier Science Ltd.
- Salim, Mohamed,Capretta, Alfredo
-
p. 8063 - 8069
(2007/10/03)
-
- The Reactions of Some Tetrahydro-β-Carbolines, of Hexahydroazepinoindoles, and of Tetrahydrocarbazolones with Arenesulphonyl Azides
-
2,9-Dimethyl-1,2,3,4-tetrahydro-1-oxo-β-carboline and 2,9-dimethyl-1,2,3,4-tetrahydro-β-carboline react with arenesulphonyl azides forming indoline-3-spiropyrrolidines; 2,10-dimethyl-3,4,5,10-tetrahydroazepinoindol-1(2H)-0ne and 2,10-dimethyl-1,2,3
- Bailey, A. Sydney,Vandrevala, Marazban H.
-
p. 1512 - 1515
(2007/10/02)
-