A convenient catalytic asymmetric conjugate addition reaction to enones using alkylzirconium reagents
Alkylzirconium reagents undergo highly enantioselective copper-catalysed 1,4-addition reaction to cyclic enones. These reactions use alkylmetal species generated in situ from alkenes and the Schwartz reagent, and do not require premade organometallic reag
Maksymowicz, Rebecca M.,Sidera, Mireia,Roth, Philippe M. C.,Fletcher, Stephen P.
supporting information
p. 2662 - 2668
(2013/10/21)
Acceleration of the conjugate addition of diethyl zinc to enones by either Cu(OTf)2 or trivalent phosphorus ligands
The conjugate addition of diethyl zinc to enones under copper catalysis occurs well with copper (II) trifiate. Other copper salts need a phosphine or phosphite ligand to be efficient. The best combination is copper (II) triflate and triethyl phosphite. A very small amount of copper (II) triflate (0.5%) and triehtyl phosphite (1%) are enough for high yields.
Alexakis,Vastra,Mangeney
p. 7745 - 7748
(2007/10/03)
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