PROBLEM TO BE SOLVED: To provide oxo-hydroquinazolines that are useful as selective thyroid stimulating hormone receptor (TSHR) agonists and may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder. SOLUTION: The present invention provides compounds represented by a formula in the figure. [R1-R4 are each independently H, hydroxyl or the like; R5 is -CH2-Ph; A is -N=C(R15)- (where a bond at the left end bonds to the benzene ring in the formula and a bond at the right end bonds to the nitrogen heteroatom in the formula) or the like; and R15 is phenyl having specific substituents.] COPYRIGHT: (C)2015,JPOandINPIT
Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
Disclosed are oxo-hydroquinazolines of formula I that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.
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(2010/05/13)
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