- ODORANTS AND COMPOSITIONS COMPRISING ODORANTS
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The present invention relates to new classes of odorous 3-(2- methylenealkoxy)alkanenitrile derivatives of formula (I) which are useful as fragrance or flavor materials in particular in providing dry, woody, dusty, earthy, and/or patchouli notes together with optional coriander, aldehydic, citrus, mandarin, pear, cinnamon, and/ or petal floral-like notes to perfume, aroma or deodorizing/masking compositions.
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Page/Page column 32-33
(2021/10/22)
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- Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers
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A series of oxazolidinone and indole derivatives were synthesized and evaluated as IL-6 signaling blockers by measuring the effects of these compounds on IL-6-induced luciferase expression in human hepatocarcinoma HepG2 cells transfected with p-STAT3-Luc. Among different compounds screened, compound 4d was emerged as the most potent IL-6 signaling blockers with IC50 value of 5.9 μM which was much better than (+)-Madindoline A (IC50 = 21 μM), a known inhibitor of IL-6.
- Singh, Sarbjit,Gajulapati, Veeraswamy,Gajulapati, Kondaji,Goo, Ja-Il,Park, Yeon-Hwa,Jung, Hwa Young,Lee, Sung Yoon,Choi, Jung Ho,Kim, Young Kook,Lee, Kyeong,Heo, Tae-Hwe,Choi, Yongseok
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supporting information
p. 1282 - 1286
(2016/02/23)
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- Lewis Acid Catalyzed Formal Intramolecular [3 + 3] Cross-Cycloaddition of Cyclopropane 1,1-Diesters for Construction of Benzobicyclo[2.2.2]octane Skeletons
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A novel Lewis acid catalyzed formal intramolecular [3 + 3] cross-cycloaddition (IMCC) of cyclopropane 1,1-diesters has been successfully developed. This supplies an efficient and conceptually new strategy for construction of bridged bicyclo[2.2.2]octane skeletons. This [3 + 3]IMCC could be run up to gram scale and from easily prepared starting materials. This [3 + 3]IMCC, together with our previously reported [3 + 2]IMCC strategy, can afford either the bicyclo[2.2.2]octane or bicyclo[3.2.1]octane skeletons from the similar starting materials by regulating the substituents on vinyl group.
- Ma, Weiwei,Fang, Jie,Ren, Jun,Wang, Zhongwen
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supporting information
p. 4180 - 4183
(2015/09/15)
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- Sequential asymmetric catalysis in Michael-Michael-Michael-aldol reactions: Merging organocatalysis with photoredox catalysis in a one-pot enantioselective synthesis of highly functionalized decalines bearing a quaternary carbon stereocenter
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An expedited method has been developed for the enantioselective synthesis of highly functionalized decaline systems containing seven contiguous stereogenic centers with high enantioselectivities (>99% ee). The one-pot methodology comprises a cascade of organocatalytic double Michael-photocatalyzed Michael-aldol reactions of ethyl 2-bromo-6-formylhex-2-enoate, β-alkyl-α,β-unsaturated aldehydes, and α-alkyl-α, β-unsaturated aldehydes. The structure and absolute configuration of an appropriate product were confirmed by X-ray analysis.
- Hong, Bor-Cherng,Lin, Cheng-Wei,Liao, Wei-Kai,Lee, Gene-Hsiang
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supporting information
p. 6258 - 6261
(2014/01/17)
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- REGENERATION OF A HYDROFORMYLATION CATALYST DURING HYDROFORMYLATION
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A method for hydroformylating or hydrocarbonylating a substrate having a carbon-carbon double or triple bond or both is described. The method comprises exposing the substrate to a hydroformylation catalyst under an atmosphere comprising carbon monoxide and hydrogen in the presence of a regeneration reagent so as to form a product. The regeneration reagent is such that it is capable of at least partially reversing poisoning of the hydroformylation catalyst by a diene or an alkyne or both.
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Page/Page column 16-17
(2011/04/14)
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- Organoleptic Compounds
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The present invention is directed to the fragrance compounds and their intermediates and a method of improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount wherein the dotted line represents a possible single or double bond; wherein R is equal to a C3-C7 hydrocarbon moieties R1 and R2 together can be selected from the group consisting of oxygen and may form a closed ring structure represented by
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- Efficient α-methylenation of carbonyl compounds in ionic liquids at room temperature
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The application of several 1-butyl-3-methylimidazolium (BMIM) salt ionic liquids as solvent in the α-methylenation of carbonyl compounds at room temperature is reported. The ionic liquid [BMIM][NTf2] gave a clean reaction in a short time and good yields of several α-methylene carbonyl compounds. This ionic liquid was reused without affecting the reaction rates or yields over seven runs. Georg Thieme Verlag Stuttgart.
- Vale, Juliana A.,Zanchetta, Daniel F.,Moran, Paulo J. S.,Rodrigues, J. Augusto R.
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experimental part
p. 75 - 78
(2009/05/30)
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- Substituted hepta-1,6-dien-3-ones with green/fruity odours green/galbanum olfactophore model
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Following an analysis of available SAR data on green/galbanum-smelling molecules, a series of new 2-substituted hepta-1,6-dien-3-ones and their analogues were prepared and their olfactory properties evaluated. The study allowed to select efficient new odourants - potential substitutes for natural galbanum oil - and to generate an olfactophore model for the green/galbanum note.
- Bajgrowicz, Jerzy A.,Berg-Schultz, Katja,Brunner, Gerhard
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p. 2931 - 2946
(2007/10/03)
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- β-Trichlorostannyl Ketones and Aldehydes. Preparation and Facile Amine-Induced Dehydrostannation Leading to α-Methylene Ketones and Aldehydes
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Ring-opening reactions of siloxycyclopropanes 1 with SnCl4 take place under mild reaction conditions and site-selectively to give β-trichlorostannyl ketones and aldehydes 3 in high yields.The β-trichlorostannyl ketones and aldehydes thus obtained readily undergo base-induced dehydrotrichlorostannation at room temperature to give the corresponding α-methylene ketones and aldehydes 4.The reactions are quite general for amines, such as pyridine, triethylamine, N,N,N',N',-tetramethylethylenediamine (TMEDA), and 1,4-diazabicyclooctane (DABCO), and the yields are good to high.One-pot conversion from siloxycyclopropanes 1 to α-methylene ketones or aldehydes 4 by consecutive treatment of 1 with SnCl4 and TMEDA is also successful.The 1H NMR, 13C NMR, 119Sn NMR, and IR spectral properties of β-stannyl ketones and aldehydes are also reported.
- Nakahira, Hiroyuki,Ryu, Ilhyong,Ikebe, Masanobu,Oku, Yoshiaki,Ogawa, Akiya,et al.
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- Carbon-Carbon Bond Formation by the Use of Chloroiodomethane as a C1 Unit. III. A Convenient Synthesis of the Mannich Base from Enol Silyl Ether by a Combination of Chloroiodomethane and N,N,N',N'-Tetramethylmethanediamine
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The Mannich dimethylaminomethylation of carbonyl compounds is conveniently carried out via enol trimethylsilyl ethers by a combination of chloroiodomethane (CH2ClI) and N,N,N',N'-tetramethylmethanediamine (TMMD) in DMSO as the solvent at ambient temperatute.The mechanism of the transformation is discussed on the basis of product analysis and 1H NMR spectral studies.The reagent system CH2ClI/TMMD also provides a convenient route to the Eschenmoser's salt ().
- Miyano, Sotaro,Hokari, Hiroshi,Hashimoto, Harukichi
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p. 534 - 539
(2007/10/02)
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- THE MANNICH REACTION OF CARBONYL COMPOUNDS VIA SILYL ENOL ETHERS BY A COMBINATION OF CHLOROIODOMETHANE AND N,N,N',N'-TETRAMETHYLDIAMINOMETHANE
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The Mannich dimethylaminomethylation of carbonyl compounds is conveniently carried out via trimethylsilyl enol ethers by a combination of chloroiodomethane and N,N,N',N'-tetramethyldiaminomethane in DMSO or DMF as the solvent at ambient temperature.
- Miyano, Sotaro,Hokari, Hiroshi,Mori, Akira,Hashimoto, Harukichi
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p. 1213 - 1214
(2007/10/02)
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