- ACC INHIBITORS AND USES THEREOF
-
The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
- -
-
Paragraph 0438
(2017/05/17)
-
- COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
-
A compound is represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables of Structural Formula (I) are as described in the specification and the claims. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier of excipient. A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of inhibiting or reducing the activity of HCV polymerase in a subject or in a biological in vitro sample comprises administering to the subject or to the sample a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
- -
-
Page/Page column 158
(2012/02/01)
-
- Kinase inhibitor compounds
-
The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.
- -
-
Page/Page column 24
(2009/04/24)
-
- KINASE INHIBITOR COMPOUNDS
-
The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.
- -
-
Page/Page column 54
(2008/06/13)
-
- P38 INHIBITORS AND METHODS OF USE THEREOF
-
Compounds of formula (I): in which A, B, X, Ar1, R8 and R4 have any of the meanings given in the specification, are inhibitors of p38 useful in the treatment and prevention of various disorders mediated by p38.
- -
-
Page/Page column 60-61
(2008/06/13)
-
- 3-aminopyrrolidone derivatives
-
This invention is related to compounds and use of 3-aminopyrrolidone derivatives and analogues of the following general formula (I)???whereinmis an integer from 1 to 3Xis methylene, oxygen, sulphur or a NR6 group;R1is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups;R2, R3are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups;R4, R5, R6are independently hydrogen or C1-C6 alkyl;???and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
- -
-
Page/Page column 12
(2010/02/11)
-
- Absolute configuration of α-phthalimido carboxylic acid derivatives from circular dichroism spectra
-
It is demonstrated that the Cotton effects due to the 220 nm phthalimide π-π* transition observed for a series of derivatives of α- phthalimidocarboxylic acids unequivocally reflect the amino acid absolute configuration. This method is based on the exciton coupling of the allowed transitions of the phthalimide and the carboxylic acid derivative chromophores. (C) 1999 Elsevier Science Ltd.
- Skowronek,Gawronski
-
p. 4585 - 4590
(2007/10/03)
-
- The synthesis of unusual tetrahydropyrimidine amino acids
-
The synthesis of derivatives of 2-(1-an-aminoalkyl)-4-carboxy-3,4,5,6-tetrahydropyrimidines, unusual amino acids isolated from bacterial siderophores, is described, from condensation of N-protected amino acids imidates or thiomidates with 2,4-diaminobutyrylglycine methyl ester.
- Jones,Crockett, Alan K.
-
p. 7459 - 7462
(2007/10/02)
-