- NOVEL PRODRUGS OF DITHIOL MUCOLYTIC AGENTS
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Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to N-acetylcysteine (NAC) and DTT. The compounds are represented by compounds of Formula I which embrace structures (la)-(Ib), where the structural variables are as defined herein.
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- Thioacetate deprotection
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A method of thioacetate deprotection by providing a compound of the formula R1—S—CO—R2, and reacting the compound with a quaternary ammonium cyanide salt in the presence of a protic solvent in an inert atmosphere to convert the compound to a product of the formula R1—SH. R1 is an organic group in which the bonding to sulfur is through a saturated carbon, and R2 is an aliphatic group.
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- HARDENABLE DENTAL COMPOSITIONS WITH LOW POLYMERIZATION SHRINKAGE
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The present invention features a hardenable dental composition that contains: (1) at least one cyclic allylic compound having at least one sulfur atom in the ring, and (2) at least one at least one ethylenically unsaturated compound, such as a substituted
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- Stereoselective reductase-catalysed deoxygenation of sulfoxides in aerobic and anaerobic bacteria.
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Direct and indirect evidence, of unexpected stereoselective reductase-catalysed deoxygenations of sulfoxides, was found. The deoxygenations proceeded simultaneously, with the expected dioxygenase-catalysed asymmetric sulfoxidation of sulfides, during some biotransformations with the aerobic bacterium Pseudomonas putida UV4. Stereoselective reductase-catalysed asymmetric deoxygenation of racemic alkylaryl, dialkyl and phenolic sulfoxides was observed, without evidence of the reverse sulfoxidation reaction, using anaerobic bacterial strains. A purified dimethyl sulfoxide reductase, obtained from the intact cells of the anaerobic bacterium Citrobacter braakii DMSO 11, yielded, from the corresponding racemates, enantiopure alkylaryl sulfoxide and thiosulfinate samples.
- Boyd, Derek R,Sharma, Narain D,King, Alistair W T,Shepherd, Steven D,Allen, Christopher C R,Holt, Robert A,Luckarift, Heather R,Dalton, Howard
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p. 554 - 561
(2007/10/03)
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- Synthesis, characterisation and crystal structures of new nickel complexes in S4 coordination spheres; An unprecedented rearrangement during ligand synthesis
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Two new nickel(II) complexes were synthesized with an S4 coordination environment. These complexes were synthesized by in situ deprotection of thiouronium salts in the presence of nickel(II). The ligands used are 4-mercapto-3,3-methyl-1-phenyl-
- Verhagen, Johanna A.W.,Ellis, Dianne D.,Lutz, Martin,Spek, Anthony L.,Bouwman, Elisabeth
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p. 1275 - 1280
(2007/10/03)
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- Solid Supported Reagents and Reactions. Part 21.1 Rapid and Clean Synthesis of Thiols from Halides Using Polymer-supported Hydrosulfide
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A variety of thiols are prepared from corresponding halides using polymer-supported hydrosulfide in excellent yields. Isolation of pure products by simple filtration and evaporation is an important feature of this method.
- Bandgar, Babasaheb P.,Pawar, Sanjay B.
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p. 212 - 213
(2007/10/03)
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- An Investigation of the Retro Diels-Alder Reaction as a Method for the Generation of Diatomic Sulfur
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The cyclic disulfides 2,3-dithiabicyclooct-5-ene 5, 1,4-dihydro-2,3-benzodithin 6 and hexahydro-5,8-epoxy-2,3-benzodithiin 7 have been prepared by oxidation of the corresponding dithiols.Each of these compounds has been subjected to vapour phase pyrolysis in order to determine whether a retro Diels-Alder reaction occurs, leading to the formation of diatomic sulfur (S2) and a diene.Compounds 5 and 7 both appeared to decompose in this way; in each case the expected diene was detected in the pyrolysate together with sulfur (S8).Attempts to intercept S2 and thus to obtain direct evidence for its formation were not successful.The benzodithiin 6 underwent an analogous loss of sulfur on vapour phase pyrolysis, but only as a minor reaction pathway, and this decomposition pathway was not detectable in solution pyrolyses.Solution pyrolysis of 6 in the presence of N-phenylmaleinimide gave N-phenyl-2,3-naphthalimide 21 in low yield. cis-Cyclopentene-3,5-dithiol 9 has also been prepared but no evidence could be obtained for the formation of disulfide 4 on oxidation.Reaction of the dithiol 9 with aldehydes and ketones in the presence of acids led to the formation of adducts (such as 12 and 13 from acetone) which were rapidly interconverted in acidic media.
- Gilchrist, Thomas L.,Wood, Jane E.
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- A Highly Selective Transannular Route to trans-trans-1,2,3,3a,4,5,9,10,10a,10b-Decahydropyrenes from Metacyclophanes
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The treatment of metacyclophanes with aluminum chloride gave a variety of hydropyrenes as the results of dehydrogenation, cycloisomerization, and disproportionation reactions.With ethylaluminum dichloride, however, a highly selective reaction occured to give trans-trans-1,2,3,3a,4,5,9,10,10a,10b-decahydropyrene.Revised structures were presented for cis-cis- and trans-trans-decahydropyrenes based on 13C NMR and X-ray crystallographic analyses.
- Sato, Takeo,Nishiyama, Kozaburo,Morita, Akira,Iitaka, Yoichi
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p. 2366 - 2369
(2007/10/02)
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- Studies toward Cyclic Trisulfides. Trisulfide Polymers and Sulfur Extrusion1
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Attempts were directed toward the synthesis of a variety of cyclic trisulfides, particularly by the reaction of N,N'-dibenzimidazolyl sulfide with dithiols.Only one monomeric cyclic trisulfide was prepared by this method; other cases yielded either mixtures of oligomers characterized as low molecular weight (5000) polymers or as products which spontaneously extruded sulfur to give the cyclic disulfides.We conlude that only where osmometric molecular weights or X-ray structures have been determined are monomeric cyclic trisulfides unambiguously defined.
- Harpp, David N.,Smith, Roger A.,Steliou, Kosta
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p. 2072 - 2079
(2007/10/02)
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